Modelling chase-and-run migration in heterogeneous populations

Annachiara Colombi, Marco Scianna, Kevin J. Painter, Luigi Preziosi

Research output: Contribution to journalArticle

Abstract

Cell migration is crucial for many physiological and pathological processes. During embryogenesis, neural crest cells undergo coordinated epithelial to mesenchymal transformations and migrate towards various forming organs. Here we develop a computational model to understand how mutual interactions between migrating neural crest cells (NCs) and the surrounding population of placode cells (PCs) generate coordinated migration. According to experimental findings, we implement a minimal set of hypotheses, based on a coupling between chemotactic movement of NCs in response to a placode-secreted chemoattractant (Sdf1) and repulsion induced from contact inhibition of locomotion (CIL), triggered by heterotypic NC–PC contacts. This basic set of assumptions is able to semi-quantitatively recapitulate experimental observations of the characteristic multispecies phenomenon of “chase-and-run”, where the colony of NCs chases an evasive PC aggregate. The model further reproduces a number of in vitro manipulations, including full or partial disruption of NC chemotactic migration and selected mechanisms coordinating the CIL phenomenon. Finally, we provide various predictions based on altering other key components of the model mechanisms.
Original languageEnglish
Pages (from-to)1-34
Number of pages34
JournalJournal of Mathematical Biology
Early online date29 Aug 2019
DOIs
Publication statusE-pub ahead of print - 29 Aug 2019

Fingerprint

Neural Crest
neural crest
Migration
Cell
Contact Inhibition
Modeling
Population
Cell Migration
Locomotion
Cell Movement
Contact
cells
locomotion
Physiological Phenomena
Epithelial-Mesenchymal Transition
Chemotactic Factors
Embryogenesis
Pathologic Processes
chemoattractants
Embryonic Development

Keywords

  • Agent-based model
  • Contact inhibition of locomotion
  • Invasion
  • Neural crest

ASJC Scopus subject areas

  • Modelling and Simulation
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics

Cite this

Colombi, Annachiara ; Scianna, Marco ; Painter, Kevin J. ; Preziosi, Luigi. / Modelling chase-and-run migration in heterogeneous populations. In: Journal of Mathematical Biology. 2019 ; pp. 1-34.
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Modelling chase-and-run migration in heterogeneous populations. / Colombi, Annachiara; Scianna, Marco; Painter, Kevin J.; Preziosi, Luigi.

In: Journal of Mathematical Biology, 29.08.2019, p. 1-34.

Research output: Contribution to journalArticle

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