Model systems for flavoenzyme activity: Site-isolated redox behavior in flavin-functionalized random polystyrene copolymers

Joseph B. Carroll; Brian J. Jordan; Hao Xu; Belma Erdogan; Lisa Lee; Lily Cheng; Christopher Tiernan; Graeme Cooke; Vincent M. Rotello

doi:10.1021/ol0505407

Model systems for flavoenzyme activity: Site-isolated redox behavior in flavin-functionalized random polystyrene copolymers

Joseph B. Carroll
, Brian J. Jordan
, Hao Xu
, Belma Erdogan
, Lisa Lee
, Lily Cheng
, Christopher Tiernan
, Graeme Cooke
, Vincent M. Rotello

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

A model system has been developed to study the redox behaviors of flavin derivatives appended onto random polystyrene copolymers through "click" chemistry strategies. The results demonstrate that flavin units attached onto polymers exhibit site-isolated redox behaviors, yielding new materials with electrochemically tunable associations (K_a(ox) = 450 M^-1, K_a(red) = 18 200 M^-1) to complementary diamidopyridine (DAP) functionality. © 2005 American Chemical Society.

Original language	English
Pages (from-to)	2551-2554
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	13
DOIs	https://doi.org/10.1021/ol0505407
Publication status	Published - 2005

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title = "Model systems for flavoenzyme activity: Site-isolated redox behavior in flavin-functionalized random polystyrene copolymers",

abstract = "A model system has been developed to study the redox behaviors of flavin derivatives appended onto random polystyrene copolymers through {"}click{"} chemistry strategies. The results demonstrate that flavin units attached onto polymers exhibit site-isolated redox behaviors, yielding new materials with electrochemically tunable associations (Ka(ox) = 450 M-1, Ka(red) = 18 200 M-1) to complementary diamidopyridine (DAP) functionality. {\textcopyright} 2005 American Chemical Society.",

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AU - Jordan, Brian J.

AU - Xu, Hao

AU - Erdogan, Belma

AU - Lee, Lisa

AU - Cheng, Lily

AU - Tiernan, Christopher

AU - Cooke, Graeme

AU - Rotello, Vincent M.

PY - 2005

Y1 - 2005

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AB - A model system has been developed to study the redox behaviors of flavin derivatives appended onto random polystyrene copolymers through "click" chemistry strategies. The results demonstrate that flavin units attached onto polymers exhibit site-isolated redox behaviors, yielding new materials with electrochemically tunable associations (Ka(ox) = 450 M-1, Ka(red) = 18 200 M-1) to complementary diamidopyridine (DAP) functionality. © 2005 American Chemical Society.

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JO - Organic Letters

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Model systems for flavoenzyme activity: Site-isolated redox behavior in flavin-functionalized random polystyrene copolymers

Abstract

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