Model Systems for Flavoenzyme Activity: Relationships between Cofactor Structure, Binding and Redox Properties

Yves Marie Legrand, Mark Gray, Graeme Cooke, Vincent M. Rotello

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

A series of flavins were synthesized bearing electron-withdrawing and -donating substituents. The electrochemical properties of these flavins in a nonpolar solvent were determined. The recognition of these flavins by a diamidopyridine (DAP) receptor and the effect this receptor has on flavin redox potential was also quantified. It was found that the DAP-flavin binding affinity and the reduction potentials (E1/2) for both the DAP-bound and unbound flavins correlated well with functions derived from linear free energy relationships (LFERs). These results provide insight and predictive capability for the interplay of electronics and redox state-specific interactions for both abiotic and enzymatic systems.

Original languageEnglish
Pages (from-to)15789-15795
Number of pages7
JournalJournal of the American Chemical Society
Volume125
Issue number51
DOIs
Publication statusPublished - 24 Dec 2003

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