Model Systems for Flavoenzyme Activity

Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation

Mark Gray, Allan J. Goodman, Joseph B. Carroll, Kevin Bardon, Michael Markey, Graeme Cooke, Vincent M. Rotello

Research output: Contribution to journalArticle

Abstract

(Equation presented) A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and p-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalOrganic Letters
Volume6
Issue number3
DOIs
Publication statusPublished - 5 Feb 2004

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Hydrogen Bonding
Oxidation-Reduction
Anions
4,6-dinitro-o-cresol

Cite this

Gray, M., Goodman, A. J., Carroll, J. B., Bardon, K., Markey, M., Cooke, G., & Rotello, V. M. (2004). Model Systems for Flavoenzyme Activity: Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation. Organic Letters, 6(3), 385-388. https://doi.org/10.1021/ol036279g
Gray, Mark ; Goodman, Allan J. ; Carroll, Joseph B. ; Bardon, Kevin ; Markey, Michael ; Cooke, Graeme ; Rotello, Vincent M. / Model Systems for Flavoenzyme Activity : Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation. In: Organic Letters. 2004 ; Vol. 6, No. 3. pp. 385-388.
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Gray, M, Goodman, AJ, Carroll, JB, Bardon, K, Markey, M, Cooke, G & Rotello, VM 2004, 'Model Systems for Flavoenzyme Activity: Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation', Organic Letters, vol. 6, no. 3, pp. 385-388. https://doi.org/10.1021/ol036279g

Model Systems for Flavoenzyme Activity : Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation. / Gray, Mark; Goodman, Allan J.; Carroll, Joseph B.; Bardon, Kevin; Markey, Michael; Cooke, Graeme; Rotello, Vincent M.

In: Organic Letters, Vol. 6, No. 3, 05.02.2004, p. 385-388.

Research output: Contribution to journalArticle

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