Model Systems for Flavoenzyme Activity: Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation

Mark Gray; Allan J. Goodman; Joseph B. Carroll; Kevin Bardon; Michael Markey; Graeme Cooke; Vincent M. Rotello

doi:10.1021/ol036279g

Model Systems for Flavoenzyme Activity: Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation

Mark Gray, Allan J. Goodman, Joseph B. Carroll, Kevin Bardon, Michael Markey, Graeme Cooke, Vincent M. Rotello

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

(Equation presented) A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and p-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.

Original language	English
Pages (from-to)	385-388
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	3
DOIs	https://doi.org/10.1021/ol036279g
Publication status	Published - 5 Feb 2004

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title = "Model Systems for Flavoenzyme Activity: Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation",

abstract = "(Equation presented) A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and p-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.",

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AU - Bardon, Kevin

AU - Markey, Michael

AU - Cooke, Graeme

AU - Rotello, Vincent M.

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AB - (Equation presented) A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and p-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.

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Model Systems for Flavoenzyme Activity: Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation

Abstract

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