Model Systems for Flavoenzyme Activity: Interplay of Hydrogen Bonding and Aromatic Stacking in Cofactor Redox Modulation

Mark Gray, Allan J. Goodman, Joseph B. Carroll, Kevin Bardon, Michael Markey, Graeme Cooke, Vincent M. Rotello

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

(Equation presented) A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and p-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalOrganic Letters
Volume6
Issue number3
DOIs
Publication statusPublished - 5 Feb 2004

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