Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

Hans Bouwmeester, Iseult Lynch, Hans J. P. Marvin, Kenneth A. Dawson, Markus Berges, Diane Braguer, Hugh J. Byrne, Alan Casey, Gordon Chambers, Martin J. D. Clift, Giuliano Elia, Teresa F. Fernandes, Lise B. Fjellsbo, Peter Hatto, Lucienne Juillerat, Christoph Klein, Wolfgang G. Kreyling, Carmen Nickel, Michael Riediker, Vicki Stone

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    117 Citations (Scopus)

    Abstract

    This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix.

    Original languageEnglish
    Pages (from-to)1-11
    Number of pages11
    JournalNanotoxicology
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - Mar 2011

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