Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

Hans Bouwmeester; Iseult Lynch; Hans J. P. Marvin; Kenneth A. Dawson; Markus Berges; Diane Braguer; Hugh J. Byrne; Alan Casey; Gordon Chambers; Martin J. D. Clift; Giuliano Elia; Teresa F. Fernandes; Lise B. Fjellsbo; Peter Hatto; Lucienne Juillerat; Christoph Klein; Wolfgang G. Kreyling; Carmen Nickel; Michael Riediker; Vicki Stone

doi:10.3109/17435391003775266

Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

Hans Bouwmeester, Iseult Lynch, Hans J. P. Marvin, Kenneth A. Dawson, Markus Berges, Diane Braguer, Hugh J. Byrne, Alan Casey, Gordon Chambers, Martin J. D. Clift, Giuliano Elia, Teresa F. Fernandes, Lise B. Fjellsbo, Peter Hatto, Lucienne Juillerat, Christoph Klein, Wolfgang G. Kreyling, Carmen Nickel, Michael Riediker, Vicki Stone

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Abstract

This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Nanotoxicology
Volume	5
Issue number	1
DOIs	https://doi.org/10.3109/17435391003775266
Publication status	Published - Mar 2011

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Bouwmeester, H., Lynch, I., Marvin, H. J. P., Dawson, K. A., Berges, M., Braguer, D., Byrne, H. J., Casey, A., Chambers, G., Clift, M. J. D., Elia, G., Fernandes, T. F., Fjellsbo, L. B., Hatto, P., Juillerat, L., Klein, C., Kreyling, W. G., Nickel, C., Riediker, M., & Stone, V. (2011). Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices. Nanotoxicology, 5(1), 1-11. https://doi.org/10.3109/17435391003775266

@article{27ab2507993e442882229bb10ca9f99b,

title = "Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices",

abstract = "This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix.",

author = "Hans Bouwmeester and Iseult Lynch and Marvin, {Hans J. P.} and Dawson, {Kenneth A.} and Markus Berges and Diane Braguer and Byrne, {Hugh J.} and Alan Casey and Gordon Chambers and Clift, {Martin J. D.} and Giuliano Elia and Fernandes, {Teresa F.} and Fjellsbo, {Lise B.} and Peter Hatto and Lucienne Juillerat and Christoph Klein and Kreyling, {Wolfgang G.} and Carmen Nickel and Michael Riediker and Vicki Stone",

year = "2011",

month = mar,

doi = "10.3109/17435391003775266",

language = "English",

volume = "5",

pages = "1--11",

journal = "Nanotoxicology",

issn = "1743-5390",

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Bouwmeester, H, Lynch, I, Marvin, HJP, Dawson, KA, Berges, M, Braguer, D, Byrne, HJ, Casey, A, Chambers, G, Clift, MJD, Elia, G, Fernandes, TF, Fjellsbo, LB, Hatto, P, Juillerat, L, Klein, C, Kreyling, WG, Nickel, C, Riediker, M & Stone, V 2011, 'Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices', Nanotoxicology, vol. 5, no. 1, pp. 1-11. https://doi.org/10.3109/17435391003775266

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T1 - Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

AU - Bouwmeester, Hans

AU - Lynch, Iseult

AU - Marvin, Hans J. P.

AU - Dawson, Kenneth A.

AU - Berges, Markus

AU - Braguer, Diane

AU - Byrne, Hugh J.

AU - Casey, Alan

AU - Chambers, Gordon

AU - Clift, Martin J. D.

AU - Elia, Giuliano

AU - Fernandes, Teresa F.

AU - Fjellsbo, Lise B.

AU - Hatto, Peter

AU - Juillerat, Lucienne

AU - Klein, Christoph

AU - Kreyling, Wolfgang G.

AU - Nickel, Carmen

AU - Riediker, Michael

AU - Stone, Vicki

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AB - This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix.

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DO - 10.3109/17435391003775266

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VL - 5

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JO - Nanotoxicology

JF - Nanotoxicology

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Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

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