Mild and Ligand Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones

James Jordan-Hore, Ai-Lan Lee, James N. Sanderson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Ligand-free cationic Pd(II) catalyst with NaNO3 as an additive is a highly active catalytic system for conjugate additions to sterically hindered ?-substituted cyclohexenones. More challenging ??- and ß?-substrates also react well to produce products with quaternary centers in good dr. The conjugate additions occur in a diastereoselective fashion under mild, practical and air-stable conditions, using readily available commercial reagents.
Original languageEnglish
Pages (from-to)2508-2511
Number of pages3
JournalOrganic Letters
Volume14
Issue number10
Early online date30 Apr 2012
DOIs
Publication statusPublished - 18 May 2012

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