Mild and Ligand Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones

James Jordan-Hore; Ai-Lan Lee; James N.  Sanderson

doi:10.1021/ol300794a

Mild and Ligand Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones

James Jordan-Hore, Ai-Lan Lee, James N. Sanderson

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20 Citations (Scopus)

Abstract

Ligand-free cationic Pd(II) catalyst with NaNO3 as an additive is a highly active catalytic system for conjugate additions to sterically hindered ?-substituted cyclohexenones. More challenging ??- and ß?-substrates also react well to produce products with quaternary centers in good dr. The conjugate additions occur in a diastereoselective fashion under mild, practical and air-stable conditions, using readily available commercial reagents.

Original language	English
Pages (from-to)	2508-2511
Number of pages	3
Journal	Organic Letters
Volume	14
Issue number	10
Early online date	30 Apr 2012
DOIs	https://doi.org/10.1021/ol300794a
Publication status	Published - 18 May 2012

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10.1021/ol300794a

http://pubs.acs.org/doi/abs/10.1021/ol300794a

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title = "Mild and Ligand Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones",

abstract = "Ligand-free cationic Pd(II) catalyst with NaNO3 as an additive is a highly active catalytic system for conjugate additions to sterically hindered ?-substituted cyclohexenones. More challenging ??- and {\ss}?-substrates also react well to produce products with quaternary centers in good dr. The conjugate additions occur in a diastereoselective fashion under mild, practical and air-stable conditions, using readily available commercial reagents.",

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AU - Jordan-Hore, James

AU - Lee, Ai-Lan

AU - Sanderson, James N.

PY - 2012/5/18

Y1 - 2012/5/18

N2 - Ligand-free cationic Pd(II) catalyst with NaNO3 as an additive is a highly active catalytic system for conjugate additions to sterically hindered ?-substituted cyclohexenones. More challenging ??- and ß?-substrates also react well to produce products with quaternary centers in good dr. The conjugate additions occur in a diastereoselective fashion under mild, practical and air-stable conditions, using readily available commercial reagents.

AB - Ligand-free cationic Pd(II) catalyst with NaNO3 as an additive is a highly active catalytic system for conjugate additions to sterically hindered ?-substituted cyclohexenones. More challenging ??- and ß?-substrates also react well to produce products with quaternary centers in good dr. The conjugate additions occur in a diastereoselective fashion under mild, practical and air-stable conditions, using readily available commercial reagents.

U2 - 10.1021/ol300794a

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M3 - Article

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JO - Organic Letters

JF - Organic Letters

IS - 10

ER -

Mild and Ligand Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones

Abstract

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