Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems

M. Mijajlovic, D. Wright, V. Zivkovic, J. X. Bi, M. J. Biggs

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Lipid vesicles have received significant attention in areas ranging from pharmaceutical and biomedical engineering to novel materials and nanotechnology. Microfluidic-based synthesis of liposomes offers a number of advantages over the more traditional synthesis methods such as extrusion and sonication. One such microfluidic approach is microfluidic hydrodynamic focusing (MHF), which has been used to synthesize nanoparticles and vesicles of various lipids. We show here that this method can be utilized in synthesis of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) vesicles with controllable size. Since POPC is among the primary constituents of cellular membranes, this work is of direct applicability to modelling of biological systems and development of nano-containers with higher biologic compatibility for pharmaceutical and medical applications.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Volume104
DOIs
Publication statusPublished - 1 Apr 2013

Keywords

  • Artificial cells
  • Drug delivery
  • Liposomes
  • Microfluidics
  • Model biological systems

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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