Microfluidic blood plasma separation for medical diagnostics: is it worth it?

Witold Szymon Mielczarek, E. A. Obaje, T. T. Bachmann, Maïwenn Kersaudy-Kerhoas

Research output: Contribution to journalArticle

55 Citations (Scopus)
126 Downloads (Pure)

Abstract

Circulating biomarkers are on the verge of becoming powerful diagnostic tools for various human diseases. However, the complex sample composition makes it difficult to detect biomarkers directly from blood at the bench or at the point-of-care. Blood cells are often a source of variability of the biomarker signal. While the interference of hemoglobin is a long known source of variability, the release of nucleic acids and other cellular components from hemocytes is a new concern for measurement and detection of circulating extracellular markers. Research into miniaturised blood plasma separation has been thriving in the last 10 years (2006-2016). Most point-of-care systems need microscale blood plasma separation, but developed solutions differ in complexity and sample volume range. But could blood plasma separation be avoided completely? This focused review weights the advantages and limits of miniaturised blood plasma separation and highlights the most interesting advances in direct capture as well as smart blood plasma separation.

Original languageEnglish
Pages (from-to)3441-3448
Number of pages8
JournalLab on a Chip
Volume16
Issue number18
Early online date1 Aug 2016
DOIs
Publication statusPublished - 21 Sep 2016

Keywords

  • OF-CARE APPLICATIONS
  • CARDIAC TROPONIN-I
  • WHOLE-BLOOD
  • SEASONAL PSEUDOHYPERKALEMIA
  • MYOCARDIAL-INFARCTION
  • HEMOLYSIS
  • CHIP
  • EXTRACTION
  • DIELECTROPHORESIS
  • SEDIMENTATION

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