Microbial antagonism: a neglected avenue of natural products research

J. Grant Burgess, Elizabeth M. Jordan, Migena Bregu, Andrew Mearns-Spragg, Kenneth G. Boyd

    Research output: Contribution to journalArticle

    Abstract

    Competition amongst microbes for space and nutrients in the marine environment is a powerful selective force which has led to the evolution of a variety of effective strategies for colonising and growing on surfaces. We are particularly interested in the chemical ecology of marine epibiotic bacteria which live on the surfaces of marine algae or invertebrates. Over 400 strains of surface-associated bacteria from various species of seaweed and invertebrate from Scottish coastal waters were isolated and 35% of them shown to produce antimicrobial compounds. This is a much higher proportion than free living marine isolates or soil bacteria. In addition, many strains which did not normally produce antibiotics could be induced to do so by exposing them to small amounts of live cells, supernatants from other bacterial cultures or other chemicals. Thus the number of strains able to produce antibiotics appears to be much higher than previously thought. Induction of antibiotic production was elicited by other marine epibionts and also by terrestrial human pathogens such as Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. An understanding of this type of chemical induction and the factors regulating non-constitutive secretion of antimicrobial compounds will allow more effective strategies for searching for new chemotherapeutic antibiotics to be designed. © 1999 Elsevier B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)27-32
    Number of pages6
    JournalProgress in Industrial Microbiology
    Volume35
    Issue numberC
    DOIs
    Publication statusPublished - 1999

    Fingerprint

    antagonism
    antibiotics
    bacterium
    invertebrate
    chemical ecology
    seaweed
    secretion
    coastal water
    marine environment
    pathogen
    alga
    product
    nutrient
    soil
    chemical

    Keywords

    • Antibiotic
    • Marine epibiotic bacteria
    • Microbial antagonism

    Cite this

    Burgess, J. G., Jordan, E. M., Bregu, M., Mearns-Spragg, A., & Boyd, K. G. (1999). Microbial antagonism: a neglected avenue of natural products research. Progress in Industrial Microbiology, 35(C), 27-32. https://doi.org/10.1016/S0079-6352(99)80094-0
    Burgess, J. Grant ; Jordan, Elizabeth M. ; Bregu, Migena ; Mearns-Spragg, Andrew ; Boyd, Kenneth G. / Microbial antagonism : a neglected avenue of natural products research. In: Progress in Industrial Microbiology. 1999 ; Vol. 35, No. C. pp. 27-32.
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    Burgess, JG, Jordan, EM, Bregu, M, Mearns-Spragg, A & Boyd, KG 1999, 'Microbial antagonism: a neglected avenue of natural products research', Progress in Industrial Microbiology, vol. 35, no. C, pp. 27-32. https://doi.org/10.1016/S0079-6352(99)80094-0

    Microbial antagonism : a neglected avenue of natural products research. / Burgess, J. Grant; Jordan, Elizabeth M.; Bregu, Migena; Mearns-Spragg, Andrew; Boyd, Kenneth G.

    In: Progress in Industrial Microbiology, Vol. 35, No. C, 1999, p. 27-32.

    Research output: Contribution to journalArticle

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