Abstract
Deprotonation of a chiral alpha-oxygenated nitrile with the base 2,2,6,6-tetramethylpiperidylmagnesiumchloride, TMPMgCl, gives rise to a chiral magnesiated nitrile, and thisanion has sufficient configurational stability at low temperature to allow the formation ofhighly enantiomerically enriched substituted nitrile products after electrophilic quench.
Original language | English |
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Pages (from-to) | 601-608 |
Number of pages | 8 |
Journal | Comptes Rendus Chimie |
Volume | 20 |
Issue number | 6 |
Early online date | 21 Dec 2016 |
DOIs | |
Publication status | Published - Jun 2017 |