Metalation-Substitution of an α-Oxygenated Chrial Nitrile

Madeha Alshawish, Graeme Barker, Nicholas D. Measom, Iain Coldham

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
33 Downloads (Pure)


Deprotonation of a chiral alpha-oxygenated nitrile with the base 2,2,6,6-tetramethylpiperidylmagnesiumchloride, TMPMgCl, gives rise to a chiral magnesiated nitrile, and thisanion has sufficient configurational stability at low temperature to allow the formation ofhighly enantiomerically enriched substituted nitrile products after electrophilic quench.
Original languageEnglish
Pages (from-to)601-608
Number of pages8
JournalComptes Rendus Chimie
Issue number6
Early online date21 Dec 2016
Publication statusPublished - Jun 2017


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