Abstract
Contrary to the accepted convention, this work shows that Minisci-type C–H alkylation does not require any metal, photocatalyst, light, or prefunctionalization of the readily available and inexpensive carboxylic acids to proceed well under mild conditions. These mild conditions can be utilized for late-stage alkylations of complex molecules, including pharmaceutical compounds and light-sensitive compounds which degrade under photocatalytic conditions.
Original language | English |
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Pages (from-to) | 6863-6867 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 20 |
Issue number | 21 |
Early online date | 24 Oct 2018 |
DOIs | |
Publication status | Published - 2 Nov 2018 |
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Dive into the research topics of 'Metal-, Photocatalyst-, and Light-Free, Late-Stage C–H Alkylation of Heteroarenes and 1,4-Quinones Using Carboxylic Acids'. Together they form a unique fingerprint.Profiles
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Ai-Lan Lee
- School of Engineering & Physical Sciences - Associate Professor
- School of Engineering & Physical Sciences, Institute of Chemical Sciences - Associate Professor
Person: Academic (Research & Teaching)