Metal-, Photocatalyst-, and Light-Free, Late-Stage C–H Alkylation of Heteroarenes and 1,4-Quinones Using Carboxylic Acids

Daniel R. Sutherland, Marcos Veguillas, Conor L. Oates, Ai-lan Lee

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Abstract

Contrary to the accepted convention, this work shows that Minisci-type C–H alkylation does not require any metal, photocatalyst, light, or prefunctionalization of the readily available and inexpensive carboxylic acids to proceed well under mild conditions. These mild conditions can be utilized for late-stage alkylations of complex molecules, including pharmaceutical compounds and light-sensitive compounds which degrade under photocatalytic conditions.
Original languageEnglish
Pages (from-to)6863-6867
Number of pages5
JournalOrganic Letters
Volume20
Issue number21
Early online date24 Oct 2018
DOIs
Publication statusPublished - 2 Nov 2018

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