Metal-, Photocatalyst-, and Light-Free Direct C-H Acylation and Carbamoylation of Heterocycles

Matthew T. Westwood, Claire J. C. Lamb, Daniel R. Sutherland, Ai-Lan Lee

Research output: Contribution to journalArticle


Direct C-H acylations and carbamoylations of heterocycles can now be readily achieved without requiring any conventional metal, photocatalyst, electrocatalysis, or light activation, thus significantly improving on sustainability, costs, toxicity, waste, and simplicity of the operational procedure. These mild conditions are also suitable for gram-scale reactions and late-stage functionalizations of complex molecules, including pharmaceuticals, N,N-ligands, and light-sensitive molecules.

Original languageEnglish
Pages (from-to)7119-7123
Number of pages5
JournalOrganic Letters
Issue number17
Early online date9 Aug 2019
Publication statusPublished - 6 Sep 2019


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this