Metal-, Photocatalyst-, and Light-Free Direct C-H Acylation and Carbamoylation of Heterocycles

Matthew T. Westwood, Claire J. C. Lamb, Daniel R. Sutherland, Ai-Lan Lee

Research output: Contribution to journalArticle

Abstract

Direct C-H acylations and carbamoylations of heterocycles can now be readily achieved without requiring any conventional metal, photocatalyst, electrocatalysis, or light activation, thus significantly improving on sustainability, costs, toxicity, waste, and simplicity of the operational procedure. These mild conditions are also suitable for gram-scale reactions and late-stage functionalizations of complex molecules, including pharmaceuticals, N,N-ligands, and light-sensitive molecules.

Original languageEnglish
Pages (from-to)7119-7123
Number of pages5
JournalOrganic Letters
Volume21
Issue number17
Early online date9 Aug 2019
DOIs
Publication statusPublished - 6 Sep 2019

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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