Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Yukinori Okada; Xueling Sim; Min Jin Go; Jer-Yuarn Wu; Dongfeng Gu; Fumihiko Takeuchi; Atsushi Takahashi; Shiro Maeda; Tatsuhiko Tsunoda; Peng Chen; Su-Chi Lim; Tien-Yin Wong; Jianjun Liu; Terri L. Young; Tin Aung; Mark Seielstad; Yik-Ying Teo; Young Jin Kim; Jong-Young Lee; Bok-Ghee Han; Daehee Kang; Chien-Hsiun Chen; Fuu-Jen Tsai; Li-Ching Chang; S.-J. Cathy Fann; Hao Mei; Dabeeru C. Rao; James E. Hixson; Shufeng Chen; Tomohiro Katsuya; Masato Isono; Toshio Ogihara; John C. Chambers; Weihua Zhang; Jaspal S. Kooner; The KidneyGen Consortium; The CKDGen Consortium; Eva Albrecht; The GUGC consortium; Kazuhiko Yamamoto; Michiaki Kubo; Yusuke Nakamura; Naoyuki Kamatani; Norihiro Kato; Jiang He; Yuan-Tsong Chen; Yoon Shin Cho; E.-Shyong Tai; Toshihiro Tanaka

doi:10.1038/ng.2352

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Yukinori Okada
, Xueling Sim
, Min Jin Go
, Jer-Yuarn Wu
, Dongfeng Gu
, Fumihiko Takeuchi
, Atsushi Takahashi
, Shiro Maeda
, Tatsuhiko Tsunoda
, Peng Chen
, Su-Chi Lim
, Tien-Yin Wong
, Jianjun Liu
, Terri L. Young
, Tin Aung
, Mark Seielstad
, Yik-Ying Teo
, Young Jin Kim
, Jong-Young Lee
, Bok-Ghee Han

Daehee Kang, Chien-Hsiun Chen, Fuu-Jen Tsai, Li-Ching Chang, S.-J. Cathy Fann, Hao Mei, Dabeeru C. Rao, James E. Hixson, Shufeng Chen, Tomohiro Katsuya, Masato Isono, Toshio Ogihara, John C. Chambers, Weihua Zhang, Jaspal S. Kooner, The KidneyGen Consortium, The CKDGen Consortium, Eva Albrecht, The GUGC consortium, Kazuhiko Yamamoto, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani, Norihiro Kato, Jiang He, Yuan-Tsong Chen, Yoon Shin Cho, E.-Shyong Tai, Toshihiro Tanaka

Research output: Contribution to journal › Article › peer-review

254 Citations (Scopus)

Abstract

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital-or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10-8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

Original language	English
Pages (from-to)	904-909
Number of pages	6
Journal	Nature Genetics
Volume	44
Issue number	8
DOIs	https://doi.org/10.1038/ng.2352
Publication status	Published - 15 Jul 2012

ASJC Scopus subject areas

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng.2352

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Okada, Y., Sim, X., Go, M. J., Wu, J.-Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S.-C., Wong, T.-Y., Liu, J., Young, T. L., Aung, T., Seielstad, M., Teo, Y.-Y., Kim, Y. J., Lee, J.-Y., ... Tanaka, T. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44(8), 904-909. https://doi.org/10.1038/ng.2352

@article{7e525c2c597b4bd1a5008ce5cbbb94a7,

title = "Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations",

abstract = "Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital-or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10-8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.",

author = "Yukinori Okada and Xueling Sim and Go, \{Min Jin\} and Jer-Yuarn Wu and Dongfeng Gu and Fumihiko Takeuchi and Atsushi Takahashi and Shiro Maeda and Tatsuhiko Tsunoda and Peng Chen and Su-Chi Lim and Tien-Yin Wong and Jianjun Liu and Young, \{Terri L.\} and Tin Aung and Mark Seielstad and Yik-Ying Teo and Kim, \{Young Jin\} and Jong-Young Lee and Bok-Ghee Han and Daehee Kang and Chien-Hsiun Chen and Fuu-Jen Tsai and Li-Ching Chang and Fann, \{S.-J. Cathy\} and Hao Mei and Rao, \{Dabeeru C.\} and Hixson, \{James E.\} and Shufeng Chen and Tomohiro Katsuya and Masato Isono and Toshio Ogihara and Chambers, \{John C.\} and Weihua Zhang and Kooner, \{Jaspal S.\} and \{The KidneyGen Consortium\} and \{The CKDGen Consortium\} and Eva Albrecht and \{The GUGC consortium\} and Kazuhiko Yamamoto and Michiaki Kubo and Yusuke Nakamura and Naoyuki Kamatani and Norihiro Kato and Jiang He and Yuan-Tsong Chen and Cho, \{Yoon Shin\} and E.-Shyong Tai and Toshihiro Tanaka and Gow, \{Alan J.\}",

year = "2012",

month = jul,

day = "15",

doi = "10.1038/ng.2352",

language = "English",

volume = "44",

pages = "904--909",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "8",

}

Okada, Y, Sim, X, Go, MJ, Wu, J-Y, Gu, D, Takeuchi, F, Takahashi, A, Maeda, S, Tsunoda, T, Chen, P, Lim, S-C, Wong, T-Y, Liu, J, Young, TL, Aung, T, Seielstad, M, Teo, Y-Y, Kim, YJ, Lee, J-Y, Han, B-G, Kang, D, Chen, C-H, Tsai, F-J, Chang, L-C, Fann, S-JC, Mei, H, Rao, DC, Hixson, JE, Chen, S, Katsuya, T, Isono, M, Ogihara, T, Chambers, JC, Zhang, W, Kooner, JS, The KidneyGen Consortium, The CKDGen Consortium, Albrecht, E, The GUGC consortium, Yamamoto, K, Kubo, M, Nakamura, Y, Kamatani, N, Kato, N, He, J, Chen, Y-T, Cho, YS, Tai, E-S & Tanaka, T 2012, 'Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations', Nature Genetics, vol. 44, no. 8, pp. 904-909. https://doi.org/10.1038/ng.2352

TY - JOUR

T1 - Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

AU - Okada, Yukinori

AU - Sim, Xueling

AU - Go, Min Jin

AU - Wu, Jer-Yuarn

AU - Gu, Dongfeng

AU - Takeuchi, Fumihiko

AU - Takahashi, Atsushi

AU - Maeda, Shiro

AU - Tsunoda, Tatsuhiko

AU - Chen, Peng

AU - Lim, Su-Chi

AU - Wong, Tien-Yin

AU - Liu, Jianjun

AU - Young, Terri L.

AU - Aung, Tin

AU - Seielstad, Mark

AU - Teo, Yik-Ying

AU - Kim, Young Jin

AU - Lee, Jong-Young

AU - Han, Bok-Ghee

AU - Kang, Daehee

AU - Chen, Chien-Hsiun

AU - Tsai, Fuu-Jen

AU - Chang, Li-Ching

AU - Fann, S.-J. Cathy

AU - Mei, Hao

AU - Rao, Dabeeru C.

AU - Hixson, James E.

AU - Chen, Shufeng

AU - Katsuya, Tomohiro

AU - Isono, Masato

AU - Ogihara, Toshio

AU - Chambers, John C.

AU - Zhang, Weihua

AU - Kooner, Jaspal S.

AU - The KidneyGen Consortium

AU - The CKDGen Consortium

AU - Albrecht, Eva

AU - The GUGC consortium

AU - Yamamoto, Kazuhiko

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Kamatani, Naoyuki

AU - Kato, Norihiro

AU - He, Jiang

AU - Chen, Yuan-Tsong

AU - Cho, Yoon Shin

AU - Tai, E.-Shyong

AU - Tanaka, Toshihiro

AU - Gow, Alan J.

PY - 2012/7/15

Y1 - 2012/7/15

N2 - Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital-or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10-8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

AB - Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital-or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10-8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

UR - https://www.scopus.com/pages/publications/84864413706

U2 - 10.1038/ng.2352

DO - 10.1038/ng.2352

M3 - Article

C2 - 22797727

AN - SCOPUS:84864413706

SN - 1061-4036

VL - 44

SP - 904

EP - 909

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Abstract

ASJC Scopus subject areas

UN SDGs

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