Mechanochemical synthesis of pyrazine: dicarboxylic acid cocrystals and a study of dissociation by quantitative phase analysis

Mihails Arhangelskis, Gareth O Lloyd, William Jones

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26 Citations (Scopus)

Abstract

Cocrystals of pyrazine with dicarboxylic acids were synthesised by mechanochemical methods. Crystal structure determination was performed by single crystal and powder X-ray diffraction (PXRD). The cocrystals consist of infinite 1D hydrogen-bonded chains exploiting the familiar pyridine-carboxylic acid synthon. The kinetics of dissociation of the pyrazine: phthalic acid cocrystal was studied at non-ambient conditions using PXRD and quantitative Rietveld phase analysis. We show that the dissociation process is both temperature and humidity dependent providing useful information about a possible dissociation mechanism.

Original languageEnglish
Pages (from-to)5203-5208
Number of pages6
JournalCrystEngComm
Volume14
Issue number16
DOIs
Publication statusPublished - 2012

Keywords

  • MELTING-POINT ALTERNATION
  • SOLID-STATE
  • SUPRAMOLECULAR SYNTHONS
  • MOLECULAR-COMPLEXES
  • CRYSTAL-STRUCTURES
  • CARBOXYLIC-ACIDS
  • DIFFRACTION DATA
  • SALT FORMATION
  • PHTHALIC-ACID
  • ISONICOTINAMIDE

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