Mathematical models for cell-matrix interactions during dermal wound healing

P. K. Maini, L. Olsen, J. A. Sherratt

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This paper contains a review of our recent work on the mathematical modeling of cell interaction with extracellular matrix components during the process of dermal wound healing. The models are of partial differential equation type and allow us to investigate in detail how various mechanochemical effects may be responsible for certain wound healing disorders such as fibrocontractive and fibroproliferative diseases. We also present a model for wound healing angiogenesis. The latter has several features in common with angiogenesis during cancer tumour growth and spread so a deeper understanding of the phenomenon in the context of wound healing may also help in the treatment of certain cancers.

Original languageEnglish
Pages (from-to)2021-2029
Number of pages9
JournalInternational Journal of Bifurcation and Chaos
Volume12
Issue number9
DOIs
Publication statusPublished - 1 Sep 2002

Keywords

  • Angiogenesis
  • Fibroproliferative disorders
  • Wound contraction

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