TY - JOUR
T1 - Mathematical modelling of extracellular matrix dynamics using discrete cells
T2 - Fiber orientation and tissue regeneration
AU - Dallon, John C.
AU - Sherratt, Jonathan A.
AU - Maini, Philip K.
PY - 1999/8/21
Y1 - 1999/8/21
N2 - Matrix orientation plays a crucial role in determining the severity of scar tissue after dermal wounding. We present a model framework which allows us to examine the interaction of many of the factors involved in orientation and alignment. Within this framework, cells are considered as discrete objects, while the matrix is modelled as a continuum. Using numerical simulations, we investigate the effect on alignment of changing cell properties and of varying cell interactions with collagen and fibrin.
AB - Matrix orientation plays a crucial role in determining the severity of scar tissue after dermal wounding. We present a model framework which allows us to examine the interaction of many of the factors involved in orientation and alignment. Within this framework, cells are considered as discrete objects, while the matrix is modelled as a continuum. Using numerical simulations, we investigate the effect on alignment of changing cell properties and of varying cell interactions with collagen and fibrin.
U2 - 10.1006/jtbi.1999.0971
DO - 10.1006/jtbi.1999.0971
M3 - Article
C2 - 10441462
SN - 0022-5193
VL - 199
SP - 449
EP - 471
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 4
ER -