Male subfertility and oxidative stress

Emily P. P. Evans; Jorien T. M. Scholten; Aldona Mzyk; Claudia Reyes-San-Martin; Arturo Elías-Llumbet; Thamir Hamoh; Eus G. J. M. Arts; Romana Schirhagl; Astrid E. P. Cantineau

doi:10.1016/j.redox.2021.102071

Male subfertility and oxidative stress

Emily P. P. Evans
, Jorien T. M. Scholten
, Aldona Mzyk
, Claudia Reyes-San-Martin
, Arturo Elías-Llumbet
, Thamir Hamoh
, Eus G. J. M. Arts
, Romana Schirhagl^*
, Astrid E. P. Cantineau^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

To date 15% of couples are suffering from infertility with 45–50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to increase. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

Original language	English
Article number	102071
Journal	Redox Biology
Volume	46
Early online date	18 Jul 2021
DOIs	https://doi.org/10.1016/j.redox.2021.102071
Publication status	Published - Oct 2021

Keywords

Reactive oxygen species
Oxidative stress
Infertility
Subfertility
Sperm

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title = "Male subfertility and oxidative stress",

abstract = "To date 15\% of couples are suffering from infertility with 45{\textendash}50\% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to increase. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.",

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doi = "10.1016/j.redox.2021.102071",

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AU - Evans, Emily P. P.

AU - Scholten, Jorien T. M.

AU - Mzyk, Aldona

AU - Reyes-San-Martin, Claudia

AU - Elías-Llumbet, Arturo

AU - Hamoh, Thamir

AU - Arts, Eus G. J. M.

AU - Schirhagl, Romana

AU - Cantineau, Astrid E. P.

PY - 2021/10

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AB - To date 15% of couples are suffering from infertility with 45–50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to increase. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

KW - Reactive oxygen species

KW - Oxidative stress

KW - Infertility

KW - Subfertility

KW - Sperm

U2 - 10.1016/j.redox.2021.102071

DO - 10.1016/j.redox.2021.102071

M3 - Article

SN - 2213-2317

VL - 46

JO - Redox Biology

JF - Redox Biology

M1 - 102071

ER -

Male subfertility and oxidative stress

Abstract

Keywords

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