Macrophage dynamics in diabetic wound dealing

Helen V. Waugh, Jonathan A. Sherratt

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Wound healing in diabetes is a complex process, characterised by a chronic inflammation phase. The exact mechanism by which this occurs is not fully understood, and whilst several treatments for healing diabetic wounds exist, very little research has been conducted towards the causes of the extended inflammation phase. We describe a mathematical model which offers a possible explanation for diabetic wound healing in terms of the distribution of macrophage phenotypes being altered in the diabetic patient compared to normal wound repair. As a consequence of this, we put forward a suggestion for treatment based on rectifying the macrophage phenotype imbalance. © Society for Mathematical Biology 2006.

Original languageEnglish
Pages (from-to)197-207
Number of pages11
JournalBulletin of Mathematical Biology
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 2006

Keywords

  • Diabetes
  • Macrophages
  • Wound healing

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