TY - JOUR
T1 - Macrophage dynamics in diabetic wound dealing
AU - Waugh, Helen V.
AU - Sherratt, Jonathan A.
PY - 2006/1
Y1 - 2006/1
N2 - Wound healing in diabetes is a complex process, characterised by a chronic inflammation phase. The exact mechanism by which this occurs is not fully understood, and whilst several treatments for healing diabetic wounds exist, very little research has been conducted towards the causes of the extended inflammation phase. We describe a mathematical model which offers a possible explanation for diabetic wound healing in terms of the distribution of macrophage phenotypes being altered in the diabetic patient compared to normal wound repair. As a consequence of this, we put forward a suggestion for treatment based on rectifying the macrophage phenotype imbalance. © Society for Mathematical Biology 2006.
AB - Wound healing in diabetes is a complex process, characterised by a chronic inflammation phase. The exact mechanism by which this occurs is not fully understood, and whilst several treatments for healing diabetic wounds exist, very little research has been conducted towards the causes of the extended inflammation phase. We describe a mathematical model which offers a possible explanation for diabetic wound healing in terms of the distribution of macrophage phenotypes being altered in the diabetic patient compared to normal wound repair. As a consequence of this, we put forward a suggestion for treatment based on rectifying the macrophage phenotype imbalance. © Society for Mathematical Biology 2006.
KW - Diabetes
KW - Macrophages
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=33746616524&partnerID=8YFLogxK
U2 - 10.1007/s11538-005-9022-3
DO - 10.1007/s11538-005-9022-3
M3 - Article
C2 - 16794927
SN - 0092-8240
VL - 68
SP - 197
EP - 207
JO - Bulletin of Mathematical Biology
JF - Bulletin of Mathematical Biology
IS - 1
ER -