Lung cancer mortality among European rock/slag wool workers: Exposure-response analysis

Dario Consonni, Paolo Boffetta, Aage Andersen, Jenny Chang-Claude, John W. Cherrie, Gilles Ferro, Rainer Frentzel-Beyme, Johnni Hansen, Jørgen Olsen, Nils Plato, Peter Westerholm, Rodolfo Saracci

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Objectives: The purpose was to analyze the relationship between semi-quantitative indices of exposure to man-made vitreous fibers and lung cancer mortality among European rock/slag wool (RSW) workers. Methods: The study population comprised 9603 male workers employed in RSW production in seven factories in Denmark, Norway, Sweden, and Germany, followed up for mortality as of 1990-91. Estimates of past exposure to respirable fibers were used to calculate cumulative exposure with a 15-year lag and maximum annual exposure based on employment history up to 1977. Rate ratios were estimated via multivariate Poisson regression, adjusting for country, age, calendar year, time since first employment, and employment status. Results: A total of 159 lung cancer deaths were included in the analysis of which 97 among workers with more than one year of employment. We found nonstatistically significant trends in lung cancer risk according to cumulative exposure. Relative risks (RR) in the four quartiles were 1.0 (reference), 1.3 (95 percent confidence interval [CI] 0.8-2.4), 1.2 (CI 0.7-2.1), and 1.5 (CI 0.7-3.0, P test for trend = 0.4). When workers with less than one year of employment were excluded, there was no increased risk; the RRs in the four quartiles were 1.0, 0.9 (CI 0.4-2.0), 0.8 (CI 0.3-1.9), and 1.0 (CI = 0.4-2.7). No trend was present according to maximum annual exposure. The results were not consistent among countries. Conclusions: We found a positive association between exposure to respirable fibers and lung cancer mortality. However, the lack of statistical significance, the dependence of the results on inclusion of short-term workers, the lack of consistency among countries, and the possible correlation between exposure to respirable fibers and to other agents reduce the weight of such evidence.

    Original languageEnglish
    Pages (from-to)411-416
    Number of pages6
    JournalCancer Causes and Control
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - 22 Oct 1998

    Keywords

    • Dose-response
    • Europe
    • Lung cancer
    • Man-made vitreous fibers
    • Men
    • Occupation

    ASJC Scopus subject areas

    • Oncology
    • Epidemiology
    • Cancer Research

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