Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists

Luke C. McIlvenna; David J. Muggeridge; Laura J. Forrest; Christopher Monaghan; Luke Liddle; Mia Cousins Burleigh; Nicholas Sculthorpe; Bernadette O. Fernandez; Martin Feelisch; Christopher Easton

doi:10.1016/j.jsams.2019.01.011

Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists

Luke C. McIlvenna, David J. Muggeridge, Laura J. Forrest, Christopher Monaghan, Luke Liddle, Mia Cousins Burleigh, Nicholas Sculthorpe, Bernadette O. Fernandez, Martin Feelisch, Christopher Easton

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objectives
Dietary nitrate (NO3-) supplementation and ischaemic preconditioning (IPC) can independently improve exercise performance. The purpose of this study was to explore whether NO3- supplementation, ingested prior to an IPC protocol, could synergistically enhance parameters of exercise.

Design
Double-blind randomized crossover trial.

Methods
Ten competitive male cyclists (age 34 ± 6 years, body mass 78.9 ± 4.9 kg, V̇O2peak 55 ± 4 mL·kg·min-1) completed an incremental exercise test followed by three cycling trials comprising a square-wave submaximal component and a 16.1 km time-trial. Oxygen uptake (V̇O2) and muscle oxygenation kinetics were measured throughout. The baseline (BASE) trial was conducted without any dietary intervention or IPC. In the remaining two trials, participants received 3 × 5 min bouts of lower limb bilateral IPC prior to exercise. Participants ingested NO3--rich gel (NIT+IPC) 90 min prior to testing in one trial and a low NO3- placebo in the other (PLA+IPC). Plasma NO3- and nitrite (NO2-) were measured immediately before and after application of IPC.

Results
Plasma [NO3-] and [NO2-] were higher before and after IPC in NIT+IPC compared to BASE (P<0.001) but did not differ between BASE and PLA+IPC. There were no differences in V̇O2 kinetics or muscle oxygenation parameters between trials (all P>0.4). Performance in the time-trial was similar between trials (BASE 1343 ± 72 s, PLA+IPC 1350 ± 75 s, NIT+IPC 1346 ± 83 s, P=0.98).

Conclusions
Pre-exercise IPC did not improve sub-maximal exercise or performance measures, either alone or in combination with dietary NO3- supplementation.

Original language	English
Pages (from-to)	852-857
Number of pages	6
Journal	Journal of Science and Medicine in Sport
Volume	22
Issue number	7
DOIs	https://doi.org/10.1016/j.jsams.2019.01.011
Publication status	Published - Jul 2019

Keywords

Nitric oxide
Blood flow
Hyperaemia
Nitrite
Exercise

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jsams.2019.01.011

Cite this

McIlvenna, L. C., Muggeridge, D. J., Forrest, L. J., Monaghan, C., Liddle, L., Burleigh, M. C., Sculthorpe, N., Fernandez, B. O., Feelisch, M., & Easton, C. (2019). Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists. Journal of Science and Medicine in Sport, 22(7), 852-857. https://doi.org/10.1016/j.jsams.2019.01.011

@article{dea8a1f63f5b45ecb5c58583e52491eb,

title = "Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists",

abstract = "ObjectivesDietary nitrate (NO3-) supplementation and ischaemic preconditioning (IPC) can independently improve exercise performance. The purpose of this study was to explore whether NO3- supplementation, ingested prior to an IPC protocol, could synergistically enhance parameters of exercise. DesignDouble-blind randomized crossover trial.MethodsTen competitive male cyclists (age 34 ± 6 years, body mass 78.9 ± 4.9 kg, {\.V}O2peak 55 ± 4 mL·kg·min-1) completed an incremental exercise test followed by three cycling trials comprising a square-wave submaximal component and a 16.1 km time-trial. Oxygen uptake ({\.V}O2) and muscle oxygenation kinetics were measured throughout. The baseline (BASE) trial was conducted without any dietary intervention or IPC. In the remaining two trials, participants received 3 × 5 min bouts of lower limb bilateral IPC prior to exercise. Participants ingested NO3--rich gel (NIT+IPC) 90 min prior to testing in one trial and a low NO3- placebo in the other (PLA+IPC). Plasma NO3- and nitrite (NO2-) were measured immediately before and after application of IPC.ResultsPlasma [NO3-] and [NO2-] were higher before and after IPC in NIT+IPC compared to BASE (P<0.001) but did not differ between BASE and PLA+IPC. There were no differences in {\.V}O2 kinetics or muscle oxygenation parameters between trials (all P>0.4). Performance in the time-trial was similar between trials (BASE 1343 ± 72 s, PLA+IPC 1350 ± 75 s, NIT+IPC 1346 ± 83 s, P=0.98).ConclusionsPre-exercise IPC did not improve sub-maximal exercise or performance measures, either alone or in combination with dietary NO3- supplementation. ",

keywords = "Nitric oxide, Blood flow, Hyperaemia, Nitrite, Exercise",

author = "McIlvenna, {Luke C.} and Muggeridge, {David J.} and Forrest, {Laura J.} and Christopher Monaghan and Luke Liddle and Burleigh, {Mia Cousins} and Nicholas Sculthorpe and Fernandez, {Bernadette O.} and Martin Feelisch and Christopher Easton",

year = "2019",

month = jul,

doi = "10.1016/j.jsams.2019.01.011",

language = "English",

volume = "22",

pages = "852--857",

journal = "Journal of Science and Medicine in Sport",

issn = "1440-2440",

publisher = "Elsevier Ltd",

number = "7",

}

McIlvenna, LC, Muggeridge, DJ, Forrest, LJ, Monaghan, C, Liddle, L, Burleigh, MC, Sculthorpe, N, Fernandez, BO, Feelisch, M & Easton, C 2019, 'Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists', Journal of Science and Medicine in Sport, vol. 22, no. 7, pp. 852-857. https://doi.org/10.1016/j.jsams.2019.01.011

TY - JOUR

T1 - Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists

AU - McIlvenna, Luke C.

AU - Muggeridge, David J.

AU - Forrest, Laura J.

AU - Monaghan, Christopher

AU - Liddle, Luke

AU - Burleigh, Mia Cousins

AU - Sculthorpe, Nicholas

AU - Fernandez, Bernadette O.

AU - Feelisch, Martin

AU - Easton, Christopher

PY - 2019/7

Y1 - 2019/7

N2 - ObjectivesDietary nitrate (NO3-) supplementation and ischaemic preconditioning (IPC) can independently improve exercise performance. The purpose of this study was to explore whether NO3- supplementation, ingested prior to an IPC protocol, could synergistically enhance parameters of exercise. DesignDouble-blind randomized crossover trial.MethodsTen competitive male cyclists (age 34 ± 6 years, body mass 78.9 ± 4.9 kg, V̇O2peak 55 ± 4 mL·kg·min-1) completed an incremental exercise test followed by three cycling trials comprising a square-wave submaximal component and a 16.1 km time-trial. Oxygen uptake (V̇O2) and muscle oxygenation kinetics were measured throughout. The baseline (BASE) trial was conducted without any dietary intervention or IPC. In the remaining two trials, participants received 3 × 5 min bouts of lower limb bilateral IPC prior to exercise. Participants ingested NO3--rich gel (NIT+IPC) 90 min prior to testing in one trial and a low NO3- placebo in the other (PLA+IPC). Plasma NO3- and nitrite (NO2-) were measured immediately before and after application of IPC.ResultsPlasma [NO3-] and [NO2-] were higher before and after IPC in NIT+IPC compared to BASE (P<0.001) but did not differ between BASE and PLA+IPC. There were no differences in V̇O2 kinetics or muscle oxygenation parameters between trials (all P>0.4). Performance in the time-trial was similar between trials (BASE 1343 ± 72 s, PLA+IPC 1350 ± 75 s, NIT+IPC 1346 ± 83 s, P=0.98).ConclusionsPre-exercise IPC did not improve sub-maximal exercise or performance measures, either alone or in combination with dietary NO3- supplementation.

AB - ObjectivesDietary nitrate (NO3-) supplementation and ischaemic preconditioning (IPC) can independently improve exercise performance. The purpose of this study was to explore whether NO3- supplementation, ingested prior to an IPC protocol, could synergistically enhance parameters of exercise. DesignDouble-blind randomized crossover trial.MethodsTen competitive male cyclists (age 34 ± 6 years, body mass 78.9 ± 4.9 kg, V̇O2peak 55 ± 4 mL·kg·min-1) completed an incremental exercise test followed by three cycling trials comprising a square-wave submaximal component and a 16.1 km time-trial. Oxygen uptake (V̇O2) and muscle oxygenation kinetics were measured throughout. The baseline (BASE) trial was conducted without any dietary intervention or IPC. In the remaining two trials, participants received 3 × 5 min bouts of lower limb bilateral IPC prior to exercise. Participants ingested NO3--rich gel (NIT+IPC) 90 min prior to testing in one trial and a low NO3- placebo in the other (PLA+IPC). Plasma NO3- and nitrite (NO2-) were measured immediately before and after application of IPC.ResultsPlasma [NO3-] and [NO2-] were higher before and after IPC in NIT+IPC compared to BASE (P<0.001) but did not differ between BASE and PLA+IPC. There were no differences in V̇O2 kinetics or muscle oxygenation parameters between trials (all P>0.4). Performance in the time-trial was similar between trials (BASE 1343 ± 72 s, PLA+IPC 1350 ± 75 s, NIT+IPC 1346 ± 83 s, P=0.98).ConclusionsPre-exercise IPC did not improve sub-maximal exercise or performance measures, either alone or in combination with dietary NO3- supplementation.

KW - Nitric oxide

KW - Blood flow

KW - Hyperaemia

KW - Nitrite

KW - Exercise

U2 - 10.1016/j.jsams.2019.01.011

DO - 10.1016/j.jsams.2019.01.011

M3 - Article

SN - 1440-2440

VL - 22

SP - 852

EP - 857

JO - Journal of Science and Medicine in Sport

JF - Journal of Science and Medicine in Sport

IS - 7

ER -

Lower limb ischemic preconditioning combined with dietary nitrate supplementation does not influence time-trial performance in well-trained cyclists

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this