Ligand and Base-free Pd(II)-Catalyzed Controlled Switching between Oxidative Heck and Conjugate Addition Reactions

Sarah Walker, Julian Boehnke, Pauline Elizabeth Glen, Steven Levey, Lisa Patrick, James Jordan-Hore, Ai-Lan Lee

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A simple change of solvent allows controlled and efficient switching between oxidative Heck and conjugate addition reactions on cyclic Michael acceptor substrates, catalyzed by a cationic Pd(II) catalyst system. Both reactions are ligand- and base-free and tolerant of air and moisture, and the controlled switching sheds light on some of the factors which favor one reaction over the other.
Original languageEnglish
Pages (from-to)1886–1889
Number of pages4
JournalOrganic Letters
Volume15
Issue number8
DOIs
Publication statusPublished - 19 Apr 2013

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