Lacunar stroke is associated with diffuse blood-brain barrier dysfunction

Joanna M Wardlaw, Fergus Doubal, Paul Armitage, Francesca Chappell, Trevor Carpenter, Susana Muñoz Maniega, Andrew Farrall, Cathie Sudlow, Martin Dennis, Baljean Dhillon

    Research output: Contribution to journalArticle

    Abstract

    Lacunar stroke is common (25% of ischemic strokes) and mostly because of an intrinsic cerebral microvascular disease of unknown cause. Although considered primarily to be an ischemic process, the vessel and tissue damage could also be explained by dysfunctional endothelium or blood-brain barrier (BBB) leak, not just ischemia. We tested for subtle generalized BBB leakiness in patients with lacunar stroke and control patients with cortical ischemic stroke.
    Original languageEnglish
    Pages (from-to)194-202
    Number of pages9
    JournalAnnals of Neurology
    Volume65
    Issue number2
    DOIs
    Publication statusPublished - 2009

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    Lacunar Stroke
    Blood-Brain Barrier
    Stroke
    Endothelium
    Ischemia

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    Wardlaw, J. M., Doubal, F., Armitage, P., Chappell, F., Carpenter, T., Muñoz Maniega, S., ... Dhillon, B. (2009). Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. Annals of Neurology, 65(2), 194-202. https://doi.org/10.1002/ana.21549
    Wardlaw, Joanna M ; Doubal, Fergus ; Armitage, Paul ; Chappell, Francesca ; Carpenter, Trevor ; Muñoz Maniega, Susana ; Farrall, Andrew ; Sudlow, Cathie ; Dennis, Martin ; Dhillon, Baljean. / Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. In: Annals of Neurology. 2009 ; Vol. 65, No. 2. pp. 194-202.
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    Wardlaw, JM, Doubal, F, Armitage, P, Chappell, F, Carpenter, T, Muñoz Maniega, S, Farrall, A, Sudlow, C, Dennis, M & Dhillon, B 2009, 'Lacunar stroke is associated with diffuse blood-brain barrier dysfunction', Annals of Neurology, vol. 65, no. 2, pp. 194-202. https://doi.org/10.1002/ana.21549

    Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. / Wardlaw, Joanna M; Doubal, Fergus; Armitage, Paul; Chappell, Francesca; Carpenter, Trevor; Muñoz Maniega, Susana; Farrall, Andrew; Sudlow, Cathie; Dennis, Martin; Dhillon, Baljean.

    In: Annals of Neurology, Vol. 65, No. 2, 2009, p. 194-202.

    Research output: Contribution to journalArticle

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    T1 - Lacunar stroke is associated with diffuse blood-brain barrier dysfunction

    AU - Wardlaw, Joanna M

    AU - Doubal, Fergus

    AU - Armitage, Paul

    AU - Chappell, Francesca

    AU - Carpenter, Trevor

    AU - Muñoz Maniega, Susana

    AU - Farrall, Andrew

    AU - Sudlow, Cathie

    AU - Dennis, Martin

    AU - Dhillon, Baljean

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    AB - Lacunar stroke is common (25% of ischemic strokes) and mostly because of an intrinsic cerebral microvascular disease of unknown cause. Although considered primarily to be an ischemic process, the vessel and tissue damage could also be explained by dysfunctional endothelium or blood-brain barrier (BBB) leak, not just ischemia. We tested for subtle generalized BBB leakiness in patients with lacunar stroke and control patients with cortical ischemic stroke.

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    DO - 10.1002/ana.21549

    M3 - Article

    C2 - 19260033

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    Wardlaw JM, Doubal F, Armitage P, Chappell F, Carpenter T, Muñoz Maniega S et al. Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. Annals of Neurology. 2009;65(2):194-202. https://doi.org/10.1002/ana.21549