Lacunar stroke is associated with diffuse blood-brain barrier dysfunction

Joanna M Wardlaw, Fergus Doubal, Paul Armitage, Francesca Chappell, Trevor Carpenter, Susana Muñoz Maniega, Andrew Farrall, Cathie Sudlow, Martin Dennis, Baljean Dhillon

    Research output: Contribution to journalArticlepeer-review

    278 Citations (Scopus)


    Lacunar stroke is common (25% of ischemic strokes) and mostly because of an intrinsic cerebral microvascular disease of unknown cause. Although considered primarily to be an ischemic process, the vessel and tissue damage could also be explained by dysfunctional endothelium or blood-brain barrier (BBB) leak, not just ischemia. We tested for subtle generalized BBB leakiness in patients with lacunar stroke and control patients with cortical ischemic stroke.
    Original languageEnglish
    Pages (from-to)194-202
    Number of pages9
    JournalAnnals of Neurology
    Issue number2
    Publication statusPublished - 2009


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