Label-free detection of amyloid growth with microcantilever sensors

T. P J Knowles; Wenmiao Shu; François Huber; Hans Peter Lang; Christoph Gerber; Christopher M. Dobson; Mark E. Welland

doi:10.1088/0957-4484/19/38/384007

Label-free detection of amyloid growth with microcantilever sensors

T. P J Knowles, Wenmiao Shu, François Huber, Hans Peter Lang, Christoph Gerber, Christopher M. Dobson, Mark E. Welland

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

We present an approach for sensing protein aggregation using microcantilever systems. Results from both single cantilever experiments with internal reference and multicantilever array measurements with dedicated reference cantilevers are discussed. We show that in both cases protein aggregation on the sensor can be detected through associated changes in surface stress. © IOP Publishing Ltd.

Original language	English
Article number	384007
Journal	Nanotechnology
Volume	19
Issue number	38
DOIs	https://doi.org/10.1088/0957-4484/19/38/384007
Publication status	Published - 24 Sept 2008

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10.1088/0957-4484/19/38/384007

http://iopscience.iop.org/0957-4484/19/38/384007

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title = "Label-free detection of amyloid growth with microcantilever sensors",

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AU - Gerber, Christoph

AU - Dobson, Christopher M.

AU - Welland, Mark E.

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AB - We present an approach for sensing protein aggregation using microcantilever systems. Results from both single cantilever experiments with internal reference and multicantilever array measurements with dedicated reference cantilevers are discussed. We show that in both cases protein aggregation on the sensor can be detected through associated changes in surface stress. © IOP Publishing Ltd.

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Label-free detection of amyloid growth with microcantilever sensors

Abstract

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