Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: A review

Mazher Iqbal Mohammed, M. P Y Desmulliez

Research output: Contribution to journalLiterature review

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Abstract

This review examines the current state of the art lab-on-a-chip and microfluidic based biosensor technologies used in the detection of cardiac biomarkers. The determination and quantification of blood based, cardiac biomarkers are crucial in the triage and management of a range of cardiac related conditions, where time delay has a major impact on short and longer-term outcomes of a patient. The design and manufacturing of biomarker detection systems are multi-disciplinary in nature and require researchers to have knowledge of both life sciences and engineering for the full potential of this field to be realised. This review will therefore provide a comprehensive overview of chip based immunosensing technology as applied to cardiac biomarker detection, while discussing the potential suitability and limitations of each configuration for incorporation within a clinical diagnostics device suitable for point-of-care applications. © 2011 The Royal Society of Chemistry.

Original languageEnglish
Pages (from-to)569-595
Number of pages27
JournalLab on a Chip
Volume11
Issue number4
DOIs
Publication statusPublished - 21 Feb 2011

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