Killing the dead: chemotherapeutic strategies against free-living cyst-forming protists (Acanthamoeba sp. and Balamuthia mandrillaris).

Naveed Ahmed Khan, Ruqaiyyah Siddiqui, Yousuf Aqeel, Naveed Ahmed Khan

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The opportunist free-living protists such as Acanthamoeba spp. and Balamuthia mandrillaris have become a serious threat to human life. As most available drugs target functional aspects of pathogens, the ability of free-living protists to transform into metabolically inactive cyst forms presents a challenge in treatment. It is hoped, that the development of broad spectrum antiprotist agents acting against multiple cyst-forming protists to provide target-directed inhibition will offer a viable drug strategy in the treatment of these rare infections. Here, we present a comprehensive report on upcoming drug targets, with emphasis on cyst wall biosynthesis along with the related biochemistry of encystment pathways, as we strive to bring ourselves a step closer to being able to combat these deadly diseases.
Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalThe Journal of eukaryotic microbiology
Volume60
Issue number3
DOIs
Publication statusPublished - 24 Apr 2013

Keywords

  • Acanthamoeba
  • Balamuthia
  • cyst formation
  • protists

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