Key questions for modelling COVID-19 exit strategies

Robin N. Thompson, T. Déirdre Hollingsworth, Valerie Isham, Daniel Arribas-Bel, Ben Ashby, Tom Britton, Peter Challenor, Lauren H. K. Chappell, Hannah Clapham, Nik J. Cunniffe, A. Philip Dawid, Christl A. Donnelly, Rosalind M. Eggo, Sebastian Funk, Nigel Gilbert, Paul Glendinning, Julia R. Gog, William S. Hart, Hans Heesterbeek, Thomas HouseMatt Keeling, István Z. Kiss, Mirjam E. Kretzschmar, Alun L. Lloyd, Emma S. McBryde, James M. McCaw, Trevelyan J. McKinley, Joel C. Miller, Martina Morris, Philip D. O'Neill, Kris V. Parag, Carl A. B. Pearson, Lorenzo Pellis, Juliet R. C. Pulliam, Joshua V. Ross, Gianpaolo Scalia Tomba, Bernard W. Silverman, Claudio J. Struchiner, Michael J. Tildesley, Pieter Trapman, Cerian R. Webb, Denis Mollison, Olivier Restif

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Combinations of intense non-pharmaceutical interventions (lockdowns) were introduced worldwide to reduce SARS-CoV-2 transmission. Many governments have begun to implement exit strategies that relax restrictions while attempting to control the risk of a surge in cases. Mathematical modelling has played a central role in guiding interventions, but the challenge of designing optimal exit strategies in the face of ongoing transmission is unprecedented. Here, we report discussions from the Isaac Newton Institute 'Models for an exit strategy' workshop (11-15 May 2020). A diverse community of modellers who are providing evidence to governments worldwide were asked to identify the main questions that, if answered, would allow for more accurate predictions of the effects of different exit strategies. Based on these questions, we propose a roadmap to facilitate the development of reliable models to guide exit strategies. This roadmap requires a global collaborative effort from the scientific community and policymakers, and has three parts: (i) improve estimation of key epidemiological parameters; (ii) understand sources of heterogeneity in populations; and (iii) focus on requirements for data collection, particularly in low-to-middle-income countries. This will provide important information for planning exit strategies that balance socio-economic benefits with public health.

Original languageEnglish
Article number20201405
JournalProceedings of the Royal Society B: Biological Sciences
Issue number1932
Publication statusPublished - 12 Aug 2020


  • COVID-19
  • SARS-CoV-2
  • epidemic control
  • exit strategy
  • mathematical modelling
  • uncertainty

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Environmental Science
  • General Agricultural and Biological Sciences


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