TY - JOUR
T1 - Keratinocyte growth factor signalling
T2 - A mathematical model of dermal- epidermal interaction in epidermal wound healing
AU - Wearing, Helen J.
AU - Sherratt, Jonathan A.
PY - 2000/5
Y1 - 2000/5
N2 - A wealth of growth factors are known to regulate the various cell functions involved in the repair process. An understanding of their therapeutic value is essential to achieve improved wound healing. Keratinocyte growth factor (KGF) seems to have a unique role as a mediator of mesenchymal-epithelial interactions: it originates from mesenchymal cells, yet acts exclusively on epithelial cells. In this paper, we study KGF's role in epidermal wound healing, since its production is substantially up- regulated after injury. We begin by modelling the dermal-epidermal signalling mechanism of KGF to investigate how this extra production affects the signal range. We then incorporate the effect of KGF on cell proliferation, and using travelling wave analysis we obtain an approximation for the rate of healing. Our modelling shows that the large up-regulation of KGF post-wounding extends the KGF signal range but is above optimal for the rate of wound closure. We predict that other functions of KGF may be more important than its role as a mitogen for the healing process. (C) 2000 Elsevier Science Inc.
AB - A wealth of growth factors are known to regulate the various cell functions involved in the repair process. An understanding of their therapeutic value is essential to achieve improved wound healing. Keratinocyte growth factor (KGF) seems to have a unique role as a mediator of mesenchymal-epithelial interactions: it originates from mesenchymal cells, yet acts exclusively on epithelial cells. In this paper, we study KGF's role in epidermal wound healing, since its production is substantially up- regulated after injury. We begin by modelling the dermal-epidermal signalling mechanism of KGF to investigate how this extra production affects the signal range. We then incorporate the effect of KGF on cell proliferation, and using travelling wave analysis we obtain an approximation for the rate of healing. Our modelling shows that the large up-regulation of KGF post-wounding extends the KGF signal range but is above optimal for the rate of wound closure. We predict that other functions of KGF may be more important than its role as a mitogen for the healing process. (C) 2000 Elsevier Science Inc.
KW - Dermal-epidermal interaction
KW - Keratinocyte growth factor
KW - Travelling waves
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=0034075994&partnerID=8YFLogxK
U2 - 10.1016/S0025-5564(00)00008-0
DO - 10.1016/S0025-5564(00)00008-0
M3 - Article
VL - 165
SP - 41
EP - 62
JO - Mathematical Biosciences
JF - Mathematical Biosciences
IS - 1
ER -