Is abnormal liver function correlated with food sensitisation in adults? US NHANES, 2005-2006

I. Shiue

Research output: Contribution to journalArticle

Abstract

Background: Associations between liver function and serum IgE levels have recently been observed in children. However, the relationship in adults is unclear. Therefore, it was aimed to study associations of liver function and serum total and food-specific IgE concentrations in a national and population-based study. Method: Data were retrieved from the United States National Health and Nutrition Examination Surveys, 2005-2006 including demographics, liver status tests, biomarkers, lifestyle factors, and serum total and food-specific IgE concentrations. Participants aged 20 and above were included. Analyses included t-test, chi-square test, and survey-weighted regression modelling. Results: After adjusting for age, sex, ethnicity, vitamin D, waist circumference, family poverty income ratio, total cholesterol, ever asthma, total protein, and survey weighting, abnormal gamma glutamyl transpeptidase was significantly associated with food sensitisation (peanut: OR 2.17, 95%CI 1.60-2.94, P < 0.001; egg: OR 2.55, 95%CI 1.32-4.90, P = 0.008; milk: OR 2.59, 95%CI 1.56-4.31, P = 0.001; shrimp: OR 1.81, 95%CI 1.29-2.55, P = 0.002). Moreover, both abnormal albumin and alanine transaminase were associated with egg sensitisation (OR 1.96, 95%CI 1.12-3.43, P = 0.022 and OR 2.06, 95%CI 1.04-4.09, P = 0.040, respectively). Conclusion: Abnormal liver status tests were correlated with serum food-specific IgE concentrations in adults. Future research with longitudinal design or in clinical settings may be warranted confirming or refuting the observations made in the present epidemiological study.

Original languageEnglish
Pages (from-to)361–368
JournalAllergologia et Immunopathologia
Volume43
Issue number4
Early online date1 Aug 2014
DOIs
Publication statusPublished - Aug 2015

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Nutrition Surveys
Immunoglobulin E
Food
Liver
Serum
Ovum
gamma-Glutamyltransferase
Waist Circumference
Chi-Square Distribution
Poverty
Alanine Transaminase
Vitamin D
Life Style
Epidemiologic Studies
Albumins
Milk
Asthma
Biomarkers
Cholesterol
Demography

Keywords

  • Antibody
  • Epidemiology
  • Food allergy
  • Food sensitisation
  • IgE
  • Liver function
  • Protein

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

@article{e3cf67fee11449b39e3b428f61076a5b,
title = "Is abnormal liver function correlated with food sensitisation in adults? US NHANES, 2005-2006",
abstract = "Background: Associations between liver function and serum IgE levels have recently been observed in children. However, the relationship in adults is unclear. Therefore, it was aimed to study associations of liver function and serum total and food-specific IgE concentrations in a national and population-based study. Method: Data were retrieved from the United States National Health and Nutrition Examination Surveys, 2005-2006 including demographics, liver status tests, biomarkers, lifestyle factors, and serum total and food-specific IgE concentrations. Participants aged 20 and above were included. Analyses included t-test, chi-square test, and survey-weighted regression modelling. Results: After adjusting for age, sex, ethnicity, vitamin D, waist circumference, family poverty income ratio, total cholesterol, ever asthma, total protein, and survey weighting, abnormal gamma glutamyl transpeptidase was significantly associated with food sensitisation (peanut: OR 2.17, 95{\%}CI 1.60-2.94, P < 0.001; egg: OR 2.55, 95{\%}CI 1.32-4.90, P = 0.008; milk: OR 2.59, 95{\%}CI 1.56-4.31, P = 0.001; shrimp: OR 1.81, 95{\%}CI 1.29-2.55, P = 0.002). Moreover, both abnormal albumin and alanine transaminase were associated with egg sensitisation (OR 1.96, 95{\%}CI 1.12-3.43, P = 0.022 and OR 2.06, 95{\%}CI 1.04-4.09, P = 0.040, respectively). Conclusion: Abnormal liver status tests were correlated with serum food-specific IgE concentrations in adults. Future research with longitudinal design or in clinical settings may be warranted confirming or refuting the observations made in the present epidemiological study.",
keywords = "Antibody, Epidemiology, Food allergy, Food sensitisation, IgE, Liver function, Protein",
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Is abnormal liver function correlated with food sensitisation in adults? US NHANES, 2005-2006. / Shiue, I.

In: Allergologia et Immunopathologia, Vol. 43, No. 4, 08.2015, p. 361–368.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Is abnormal liver function correlated with food sensitisation in adults? US NHANES, 2005-2006

AU - Shiue, I.

PY - 2015/8

Y1 - 2015/8

N2 - Background: Associations between liver function and serum IgE levels have recently been observed in children. However, the relationship in adults is unclear. Therefore, it was aimed to study associations of liver function and serum total and food-specific IgE concentrations in a national and population-based study. Method: Data were retrieved from the United States National Health and Nutrition Examination Surveys, 2005-2006 including demographics, liver status tests, biomarkers, lifestyle factors, and serum total and food-specific IgE concentrations. Participants aged 20 and above were included. Analyses included t-test, chi-square test, and survey-weighted regression modelling. Results: After adjusting for age, sex, ethnicity, vitamin D, waist circumference, family poverty income ratio, total cholesterol, ever asthma, total protein, and survey weighting, abnormal gamma glutamyl transpeptidase was significantly associated with food sensitisation (peanut: OR 2.17, 95%CI 1.60-2.94, P < 0.001; egg: OR 2.55, 95%CI 1.32-4.90, P = 0.008; milk: OR 2.59, 95%CI 1.56-4.31, P = 0.001; shrimp: OR 1.81, 95%CI 1.29-2.55, P = 0.002). Moreover, both abnormal albumin and alanine transaminase were associated with egg sensitisation (OR 1.96, 95%CI 1.12-3.43, P = 0.022 and OR 2.06, 95%CI 1.04-4.09, P = 0.040, respectively). Conclusion: Abnormal liver status tests were correlated with serum food-specific IgE concentrations in adults. Future research with longitudinal design or in clinical settings may be warranted confirming or refuting the observations made in the present epidemiological study.

AB - Background: Associations between liver function and serum IgE levels have recently been observed in children. However, the relationship in adults is unclear. Therefore, it was aimed to study associations of liver function and serum total and food-specific IgE concentrations in a national and population-based study. Method: Data were retrieved from the United States National Health and Nutrition Examination Surveys, 2005-2006 including demographics, liver status tests, biomarkers, lifestyle factors, and serum total and food-specific IgE concentrations. Participants aged 20 and above were included. Analyses included t-test, chi-square test, and survey-weighted regression modelling. Results: After adjusting for age, sex, ethnicity, vitamin D, waist circumference, family poverty income ratio, total cholesterol, ever asthma, total protein, and survey weighting, abnormal gamma glutamyl transpeptidase was significantly associated with food sensitisation (peanut: OR 2.17, 95%CI 1.60-2.94, P < 0.001; egg: OR 2.55, 95%CI 1.32-4.90, P = 0.008; milk: OR 2.59, 95%CI 1.56-4.31, P = 0.001; shrimp: OR 1.81, 95%CI 1.29-2.55, P = 0.002). Moreover, both abnormal albumin and alanine transaminase were associated with egg sensitisation (OR 1.96, 95%CI 1.12-3.43, P = 0.022 and OR 2.06, 95%CI 1.04-4.09, P = 0.040, respectively). Conclusion: Abnormal liver status tests were correlated with serum food-specific IgE concentrations in adults. Future research with longitudinal design or in clinical settings may be warranted confirming or refuting the observations made in the present epidemiological study.

KW - Antibody

KW - Epidemiology

KW - Food allergy

KW - Food sensitisation

KW - IgE

KW - Liver function

KW - Protein

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DO - 10.1016/j.aller.2014.02.009

M3 - Article

VL - 43

SP - 361

EP - 368

JO - Allergologia et Immunopathologia

JF - Allergologia et Immunopathologia

SN - 0301-0546

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ER -