Iron(II)-mediated fragmentation of unsaturated hydroperoxy acetals

A rapid synthetic route to 13-membered macrolides

K. J. McCullough, Y. Motomura, A. Masuyama, M. Nojima

Research output: Contribution to journalArticle

Abstract

Treatment of (1-hydroperoxy)cyclohexyloxyethyl acrylate with either iron(II) sulfate or iron(II) sulfate/copper(II) chloride affords novel 13-membered macrolides via tandem radical scission-cyclisation reactions.

Original languageEnglish
Pages (from-to)1173-1174
Number of pages2
JournalChemical Communications
Issue number11
Publication statusPublished - 7 Jun 1998

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Acetals
Macrolides
Iron
Cyclization
Sulfates
cupric chloride
acrylic acid

Cite this

McCullough, K. J. ; Motomura, Y. ; Masuyama, A. ; Nojima, M. / Iron(II)-mediated fragmentation of unsaturated hydroperoxy acetals : A rapid synthetic route to 13-membered macrolides. In: Chemical Communications. 1998 ; No. 11. pp. 1173-1174.
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Iron(II)-mediated fragmentation of unsaturated hydroperoxy acetals : A rapid synthetic route to 13-membered macrolides. / McCullough, K. J.; Motomura, Y.; Masuyama, A.; Nojima, M.

In: Chemical Communications, No. 11, 07.06.1998, p. 1173-1174.

Research output: Contribution to journalArticle

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