Ion channels in key marine invertebrates; their diversity and potential for applications in biotechnology

Euan R Brown, Stefania Piscopo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Of the intra-membrane proteins, the class that comprises voltage and ligand-gated ion channels represents the major substrate whereby signals pass between and within cells in all organisms. It has been presumed that vertebrate and particularly mammalian ion channels represent the apex of evolutionary complexity and diversity and much effort has been focused on understanding their function. However, the recent availability of cheap high throughput genome sequencing has massively broadened and deepened the quality of information across phylogeny and is radically changing this view. Here we review current knowledge on such channels in key marine invertebrates where physiological evidence is backed up by molecular sequences and expression/functional studies. As marine invertebrates represent a much greater range of phyla than terrestrial vertebrates and invertebrates together, we argue that these animals represent a highly divergent, though relatively underused source of channel novelty. As ion channels are exquisitely selective sensors for voltage and ligands, their potential and actual applications in biotechnology are manifold.
Original languageEnglish
Pages (from-to)457-467
Number of pages11
JournalBiotechnology Advances
Volume29
Issue number5
DOIs
Publication statusPublished - 2011

Fingerprint Dive into the research topics of 'Ion channels in key marine invertebrates; their diversity and potential for applications in biotechnology'. Together they form a unique fingerprint.

  • Cite this