Investigation of different hydrogels for nucleus replacement - A biomechanical study

Sandra Reitmaier, U. Wolfram, Anita Ignatius, Hans-Joachim Wilke, Jose M. Martin-Martinez, J. Silva-Correia, Joaquim Miguel Oliveira, R. L. Reis, Hendrik Schmidt

Research output: Contribution to journalArticlepeer-review


Hydrogels are considered promising for disc regeneration strategies. However, it is currently unknown whether the destruction of the natural interface between nucleus and surrounding
structures caused by nucleotomy and an inadequate annulus closure diminishes the mechanical competence of the disc. To clarify these mechanisms and to evaluate whether hydrogels are able to restore the biomechanical behaviour of the disc a combined in vivo and in vitro and approach was used.
Original languageEnglish
Article numberPresentation 1394
Pages (from-to)S51
Number of pages1
JournalJournal of Biomechanics
Publication statusPublished - 2012


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