Investigating a new drug delivery nano composite membrane system based on PVA/PCL and PVA/HA(PEG) for the controlled release of biopharmaceuticals for bone infections

Taoyu Wan, George K Stylios, Marilena Giannoudi, Peter V. Giannoudis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The capability for sustained and gradual release of pharmaceuticals is a major requirement in the development of a guided antimicrobial bacterial control system for clinical applications. In this study, PVA gels with varying constituents that were manufactured via a refreeze/thawing route, were found to have excellent potential for antimicrobial delivery for bone infections. Cefuroxime Sodium with poly(ethylene glycol) was incorporated into 2 delivery systems poly(e-caprolactone) (PCL) and hydroxyapatite (HA), by a modified emulsion process. Our results indicate that the Cefuroxime Sodium released from poly(e-caprolactone) in PVA was tailored to a sustained release over more than 45 days, while the release from hydroxyapatite PVA reach burst maximum after 20 days. These PVA hydrogel-systems were also capable of controlled and sustained release of other biopharmaceuticals.

Original languageEnglish
Pages (from-to)S39-S43
Number of pages5
JournalInjury
Volume46
Issue numberSupplement 8
DOIs
Publication statusPublished - Dec 2015

Keywords

  • bone infections
  • controlled delivery
  • drug delivery
  • nano composite
  • nano membrane
  • poly(e-caprolactone)
  • PVA hydrogels

ASJC Scopus subject areas

  • Emergency Medicine
  • Orthopedics and Sports Medicine

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