Interactions between Epac1 and ezrin in the control of endothelial barrier function

Euan Parnell, Stephen J Yarwood

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Loss of barrier function in the vasculature promotes inflammatory signalling which in turn contributes to the progression of cardiovascular disease. cAMP can protect against endothelial dysfunction through the effectors PKA (protein kinase A) and Epac (exchange protein directly activated by cAMP). The present review outlines the role of Epac1 signalling within the endothelium and, in particular, the role of Epac1 in cytoskeletal dynamics and the control of cell morphology. The actin/cytoskeleton linker ezrin will be described in terms of the growing body of evidence placing it downstream of cAMP signalling as a mediator of altered cellular morphology.

    Original languageEnglish
    Pages (from-to)274-278
    Number of pages5
    JournalBiochemical Society Transactions
    Volume42
    Issue number2
    DOIs
    Publication statusPublished - Apr 2014

    Keywords

    • Cytoskeletal Proteins
    • Cytoskeleton
    • Endothelium
    • Guanine Nucleotide Exchange Factors
    • Humans
    • Signal Transduction

    Fingerprint

    Dive into the research topics of 'Interactions between Epac1 and ezrin in the control of endothelial barrier function'. Together they form a unique fingerprint.

    Cite this