Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1

Graeme B. Bolger; Miles Douglas Houslay; Michael R. Steele; Stephen Yarwood

Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1

Graeme B. Bolger (Inventor), Miles Douglas Houslay (Inventor), Michael R. Steele (Inventor), Stephen Yarwood (Inventor)

Research output: Patent

Abstract

It has been discovered that the cAMP-specific phosphodiesterase, PDE4D5, interacts specifically and with high affinity with the Receptor for Activated C-Kinase (RACK1). The region of PDE4D5 that interacts with RACK1 was determined, and it was shown that peptides spanning this region inhibit the specific interaction of PDE4D5 and RACK1. Drugs that inhibit or stimulate this interaction should be therapeutically important for treating various conditions. A method for screening candidate drugs involves detecting inhibition or stimulation of this interaction of the peptide and RACK1. Peptides that modulate this interaction and methods of making thereof are also disclosed.

Original language	English
Patent number	WO0071080
IPC	C12Q 1/ 44 A I
Priority date	20/05/99
Publication status	Published - 30 Nov 2000

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title = "Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1",

abstract = "It has been discovered that the cAMP-specific phosphodiesterase, PDE4D5, interacts specifically and with high affinity with the Receptor for Activated C-Kinase (RACK1). The region of PDE4D5 that interacts with RACK1 was determined, and it was shown that peptides spanning this region inhibit the specific interaction of PDE4D5 and RACK1. Drugs that inhibit or stimulate this interaction should be therapeutically important for treating various conditions. A method for screening candidate drugs involves detecting inhibition or stimulation of this interaction of the peptide and RACK1. Peptides that modulate this interaction and methods of making thereof are also disclosed.",

author = "Bolger, {Graeme B.} and Houslay, {Miles Douglas} and Steele, {Michael R.} and Stephen Yarwood",

year = "2000",

month = nov,

day = "30",

language = "English",

type = "Patent",

note = "WO0071080; C12Q 1/ 44 A I",

}

TY - PAT

T1 - Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1

AU - Bolger, Graeme B.

AU - Houslay, Miles Douglas

AU - Steele, Michael R.

AU - Yarwood, Stephen

PY - 2000/11/30

Y1 - 2000/11/30

N2 - It has been discovered that the cAMP-specific phosphodiesterase, PDE4D5, interacts specifically and with high affinity with the Receptor for Activated C-Kinase (RACK1). The region of PDE4D5 that interacts with RACK1 was determined, and it was shown that peptides spanning this region inhibit the specific interaction of PDE4D5 and RACK1. Drugs that inhibit or stimulate this interaction should be therapeutically important for treating various conditions. A method for screening candidate drugs involves detecting inhibition or stimulation of this interaction of the peptide and RACK1. Peptides that modulate this interaction and methods of making thereof are also disclosed.

AB - It has been discovered that the cAMP-specific phosphodiesterase, PDE4D5, interacts specifically and with high affinity with the Receptor for Activated C-Kinase (RACK1). The region of PDE4D5 that interacts with RACK1 was determined, and it was shown that peptides spanning this region inhibit the specific interaction of PDE4D5 and RACK1. Drugs that inhibit or stimulate this interaction should be therapeutically important for treating various conditions. A method for screening candidate drugs involves detecting inhibition or stimulation of this interaction of the peptide and RACK1. Peptides that modulate this interaction and methods of making thereof are also disclosed.

M3 - Patent

M1 - WO0071080

ER -

Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1

Abstract

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