Abstract
The inhibition of mitochondrial octanoate oxidation in vitro by salicylic acid (1mM), 2,4 dinitrophenol (0.05mM) and ? resorcylic acid (2mM) was studied. Concentrations of salicylate and 2,4 dinitrophenol markedly inhibiting the mitochondrial oxidation of octanoate did not significantly affect the mitochondrial oxidation of octanoylcarnitine. All 3 compounds (0.4mM) inhibited a partially purified preparation of medium chain length acyl CoA synthetase from ox liver mitochondria. It is suggested that at least part of the inhibition of mitochondrial oxidation by salicylic and ? resorcylic acids in vitro in the concentration ranges studied is caused by the direct inhibition of the medium chain length acyl CoA synthetase.
| Original language | English |
|---|---|
| Pages (from-to) | 531-534 |
| Number of pages | 4 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 26 |
| Issue number | 7 |
| Publication status | Published - 1974 |
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