The inhibition of mitochondrial octanoate oxidation in vitro by salicylic acid (1mM), 2,4 dinitrophenol (0.05mM) and ? resorcylic acid (2mM) was studied. Concentrations of salicylate and 2,4 dinitrophenol markedly inhibiting the mitochondrial oxidation of octanoate did not significantly affect the mitochondrial oxidation of octanoylcarnitine. All 3 compounds (0.4mM) inhibited a partially purified preparation of medium chain length acyl CoA synthetase from ox liver mitochondria. It is suggested that at least part of the inhibition of mitochondrial oxidation by salicylic and ? resorcylic acids in vitro in the concentration ranges studied is caused by the direct inhibition of the medium chain length acyl CoA synthetase.
|Number of pages
|Journal of Pharmacy and Pharmacology
|Published - 1974