Inhibition of the mitochondrial oxidation of octanoate by salicyclic acid and related compounds

A. B. Graham, M. V. Park

    Research output: Contribution to journalArticle

    Abstract

    The inhibition of mitochondrial octanoate oxidation in vitro by salicylic acid (1mM), 2,4 dinitrophenol (0.05mM) and ? resorcylic acid (2mM) was studied. Concentrations of salicylate and 2,4 dinitrophenol markedly inhibiting the mitochondrial oxidation of octanoate did not significantly affect the mitochondrial oxidation of octanoylcarnitine. All 3 compounds (0.4mM) inhibited a partially purified preparation of medium chain length acyl CoA synthetase from ox liver mitochondria. It is suggested that at least part of the inhibition of mitochondrial oxidation by salicylic and ? resorcylic acids in vitro in the concentration ranges studied is caused by the direct inhibition of the medium chain length acyl CoA synthetase.

    Original languageEnglish
    Pages (from-to)531-534
    Number of pages4
    JournalJournal of Pharmacy and Pharmacology
    Volume26
    Issue number7
    Publication statusPublished - 1974

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