Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils

A. Smith-Palmer, J. Stewart, L. Fyfe

    Research output: Contribution to journalArticle

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    Abstract

    Successful infection by Listeria monocytogenes is dependent upon a range of bacterial extracellular proteins including a cytolysin termed listeriolysin O and phosphatidylcholine-specific phospholipase C. Five plant essential oils - bay, clove, cinnamon, nutmeg and thyme - significantly reduced the production of listeriolysin O by L. monocytogenes. The greatest change was observed after culture with oil of thyme, which reduced haemolysis to 52.1 haemolytic units (HU)/ml compared with 99.8 HU/ml observed with the control. Oil of clove was the only oil that also significantly reduced phosphatidylcholine-specific phospholipase C activity. These changes were observed despite the oils causing no change to the final bacterial concentration or total extracellular protein concentration.

    Original languageEnglish
    Pages (from-to)567-574
    Number of pages8
    JournalJournal of Medical Microbiology
    Volume51
    Issue number7
    Publication statusPublished - 2002

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