Inhibiting N-acyl-homoserine lactone synthesis and quenching Pseudomonas quinolone quorum sensing to attenuate virulence

Kok Gan Chan, Yi-Chia Liu, Chien-Yi Chang

    Research output: Contribution to journalArticle

    28 Citations (Scopus)
    20 Downloads (Pure)

    Abstract

    Bacteria sense their own population size, tune the expression of responding genes, and behave accordingly to environmental stimuli by secreting signaling molecules. This phenomenon is termed as quorum sensing (QS). By exogenously manipulating the signal transduction bacterial population behaviors could be controlled, which may be done through quorum quenching (QQ). QS related regulatory networks have been proven their involvement in regulating many virulence determinants in pathogenic bacteria in the course of infections. Interfering with QS signaling system could be a novel strategy against bacterial infections and therefore requires more understanding of their fundamental mechanisms. Here we review the development of studies specifically on the inhibition of production of N-acyl-homoserine lactone (AHL), a common proteobacterial QS signal. The opportunistic pathogen, Pseudomonas aeruginosa, equips the alkylquinolone (AQ)-mediated QS which also plays crucial roles in its pathogenicity. The studies in QQ targeting on AQ are also discussed.

    Original languageEnglish
    Article number1173
    JournalFrontiers in Microbiology
    Volume6
    DOIs
    Publication statusPublished - Oct 2015

    Keywords

    • Alkylquinolone
    • N-acyl-homoserine lactone
    • Pseudomonas aeruginosa
    • Pseudomonas quinolone signal
    • Quorum quenching
    • Quorum sensing

    ASJC Scopus subject areas

    • Microbiology
    • Microbiology (medical)

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