TY - JOUR
T1 - Increasing Importance of Balamuthia mandrillaris
AU - Matin, Abdul
AU - Siddiqui, Ruqaiyyah
AU - Jayasekera, Samantha
AU - Khan, Naveed Ahmed
PY - 2008/7/1
Y1 - 2008/7/1
N2 - Balamuthia mandrillaris is an emerging protozoan parasite, an agent of granulomatous amoebic encephalitis involving the central nervous system, with a case fatality rate of >98%. This review presents our current understanding of Balamuthia infections, their pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as virulence traits of Balamuthia that may be potential targets for therapeutic interventions and/or for the development of preventative measures.
AB - Balamuthia mandrillaris is an emerging protozoan parasite, an agent of granulomatous amoebic encephalitis involving the central nervous system, with a case fatality rate of >98%. This review presents our current understanding of Balamuthia infections, their pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as virulence traits of Balamuthia that may be potential targets for therapeutic interventions and/or for the development of preventative measures.
UR - https://www.scopus.com/pages/publications/47949129927
U2 - 10.1128/CMR.00056-07
DO - 10.1128/CMR.00056-07
M3 - Article
C2 - 18625680
SN - 0893-8512
VL - 21
SP - 435
EP - 448
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
IS - 3
ER -