Increasing Importance of Balamuthia mandrillaris

Abdul Matin; Ruqaiyyah Siddiqui; Samantha Jayasekera; Naveed Ahmed Khan

doi:10.1128/CMR.00056-07

Increasing Importance of Balamuthia mandrillaris

Abdul Matin
, Ruqaiyyah Siddiqui
, Samantha Jayasekera
, Naveed Ahmed Khan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

128 Citations (Scopus)

Abstract

Balamuthia mandrillaris is an emerging protozoan parasite, an agent of granulomatous amoebic encephalitis involving the central nervous system, with a case fatality rate of >98%. This review presents our current understanding of Balamuthia infections, their pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as virulence traits of Balamuthia that may be potential targets for therapeutic interventions and/or for the development of preventative measures.

Original language	English
Pages (from-to)	435-448
Number of pages	14
Journal	Clinical Microbiology Reviews
Volume	21
Issue number	3
DOIs	https://doi.org/10.1128/CMR.00056-07
Publication status	Published - 1 Jul 2008

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title = "Increasing Importance of Balamuthia mandrillaris",

abstract = "Balamuthia mandrillaris is an emerging protozoan parasite, an agent of granulomatous amoebic encephalitis involving the central nervous system, with a case fatality rate of >98\%. This review presents our current understanding of Balamuthia infections, their pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as virulence traits of Balamuthia that may be potential targets for therapeutic interventions and/or for the development of preventative measures.",

author = "Abdul Matin and Ruqaiyyah Siddiqui and Samantha Jayasekera and Khan, \{Naveed Ahmed\}",

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AU - Jayasekera, Samantha

AU - Khan, Naveed Ahmed

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Y1 - 2008/7/1

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AB - Balamuthia mandrillaris is an emerging protozoan parasite, an agent of granulomatous amoebic encephalitis involving the central nervous system, with a case fatality rate of >98%. This review presents our current understanding of Balamuthia infections, their pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as virulence traits of Balamuthia that may be potential targets for therapeutic interventions and/or for the development of preventative measures.

U2 - 10.1128/CMR.00056-07

DO - 10.1128/CMR.00056-07

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EP - 448

JO - Clinical Microbiology Reviews

JF - Clinical Microbiology Reviews

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Increasing Importance of Balamuthia mandrillaris

Abstract

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