In-vivo evaluation of microultrasound and thermometric capsule endoscopes

Holly S. Lay, Gerard Cummins, Benjamin F. Cox, Yongiang Qiu, Mihnea Vlad Turcanu, Rachael McPhillips, Ciaran Connor, Rachael Gregson, Richard Eddie Clutton, Marc Phillipe Yves Desmulliez, Sandy Cochran

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Abstract

Clinical endoscopy and colonoscopy are commonly used to investigate and diagnose disorders in the upper gastrointestinal tract and colon respectively. However, examination of the anatomically remote small bowel with conventional endoscopy is challenging. This and advances in miniaturization led to the development of video capsule endoscopy (VCE) to allow small bowel examination in a noninvasive
manner. Available since 2001, current capsule endoscopes are limited to viewing the mucosal surface only due to their reliance on optical imaging. To overcome this limitation with submucosal imaging, work is under way to implement
microultrasound (μUS) imaging in the same form as VCE devices. This paper describes two prototype capsules, termed Sonocap and Thermocap, which were developed respectively to assess the quality of μUS imaging and the maximum power
consumption that can be tolerated for such a system. The capsules were tested in vivo in the oesophagus and small bowel of porcine models. Results are presented in the form of μUS B-scans as well as safe temperature readings observed up to 100 mW in
both biological regions. These results demonstrate that acoustic coupling and μUS imaging can be achieved in vivo in the lumen of the bowel and the maximum power consumption that is possible for miniature μUS systems.
Original languageEnglish
Pages (from-to)632-639
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume66
Issue number3
Early online date5 Jul 2018
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Capsule endoscopy
  • high-frequency ultrasound
  • in vivo testing
  • microultrasound
  • safety testing
  • ultrasound array

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Lay, H. S., Cummins, G., Cox, B. F., Qiu, Y., Turcanu, M. V., McPhillips, R., Connor, C., Gregson, R., Clutton, R. E., Desmulliez, M. P. Y., & Cochran, S. (2019). In-vivo evaluation of microultrasound and thermometric capsule endoscopes. IEEE Transactions on Biomedical Engineering, 66(3), 632-639. https://doi.org/10.1109/TBME.2018.2852715