In situ micropillar compression tests of lamellar bone shows remarkable strength and ductility but no damage on the microscale

Jakob Schwiedrzik, Rejin Raghavan, Alexander Bürki, U. Wolfram, Philippe K. Zysset, Johann Michler

Research output: Contribution to journalArticle

Abstract

Bone is a hierarchical composite material featuring a cell-seeded mineralized collagen matrix. It is designed for mechanical support, metabolizing minerals and storing bone marrow. Its strength depends on the amount of mineral measured by clinical densitometry, but also on the micromechanical properties of the bone hierarchical organization. A good understanding has been reached for elastic properties on several length scales, but up to now there is a lack of data with respect to plasticity at the lower length scales. An experimental setup for micromechanical testing allowing a straightforward interpretation of the data due to the uniaxial stress state is micropillar compression. Micron sized pillars were produced by milling of the material using a focused Ga-ion beam and compressed uniaxially to extract mechanical properties such as yield stress and strength.

40 monotonic and 10 cyclic micropillar com-pression tests observed in situ in a scanning electron microscope complemented by micro-indentations and 26 macroscopic cyclic uni-axial compression tests were performed on dry ovine bone to identify its mechanical properties as well as deformation and failure mechanisms [1]. While the elastic properties measured during micropillar compression, microindentation and macroscopic compression tests were consistent, the plastic deformation and failure mechanisms differed between the two length scales. A majority of the micropillars showed a highly ductile behavior with continuous strain hardening until failure by localization in a shear plane, while the macroscopic samples failed in a quasi-brittle fashion. The microscopic compressive strength was 2.4 times higher than at the macroscale (0.75 GPa vs. 0.31 GPa), the maximum plastic strain 6 times higher. Also, cyclic compression tests showed no reduction in elastic modulus of the micropillars as opposed to the macroscopic samples.

These experiments illustrate a transition in bone under compression from ductile behaviour at the microscale to a quasi-brittle response driven by the growth of microcracks along interfaces or in the vicinity of pores associated with modulus reduction at the macroscale. The insights obtained from this study may help to improve our understanding of the fragility of bone due to ageing and disease in the future.
Original languageEnglish
Pages (from-to)740-747
Number of pages8
JournalNature Materials
Volume13
Publication statusPublished - 2014

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