In Sacchoromyces cerevisiae, impaired PRPP synthesis is accompanied by valproate and Li+ sensitivity

S. Vavassori, K. Wang, L. M. Schweizer, M. Schweizer

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    The biosynthetic intermediate PRPP (phosphoribosylpyrophosphate) has a central role in cellular biochemistry since it links carbon and nitrogen metabolism. Its importance may be reflected in the fact that, in the Saccharomyces cerevisiae (yeast) genome, there are five unlinked genes, PRS1-PRS5, each of which is theoretically capable of encoding the enzyme synthesizing PRPP. Interference with the complement of PRS genes in S. cerevisiae has far-reaching consequences for yeast physiology and has uncovered unexpected metabolic links including cell wall integrity and phospholipid metabolism. ©2005 Biochemical Society.

    Original languageEnglish
    Pages (from-to)1154-1157
    Number of pages4
    JournalBiochemical Society Transactions
    Volume33
    Issue number5
    DOIs
    Publication statusPublished - Nov 2005

    Keywords

    • CTP
    • Metabolic networking
    • Prs (phosphoribosylpyropliosphate synthetase)
    • Slt2
    • Socchoromyces cerevisiae
    • Valproate

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