In Sacchoromyces cerevisiae, impaired PRPP synthesis is accompanied by valproate and Li+ sensitivity

S. Vavassori; K. Wang; L. M. Schweizer; M. Schweizer

doi:10.1042/BST20051154

In Sacchoromyces cerevisiae, impaired PRPP synthesis is accompanied by valproate and Li⁺ sensitivity

S. Vavassori, K. Wang, L. M. Schweizer, M. Schweizer

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10 Citations (Scopus)

Abstract

The biosynthetic intermediate PRPP (phosphoribosylpyrophosphate) has a central role in cellular biochemistry since it links carbon and nitrogen metabolism. Its importance may be reflected in the fact that, in the Saccharomyces cerevisiae (yeast) genome, there are five unlinked genes, PRS1-PRS5, each of which is theoretically capable of encoding the enzyme synthesizing PRPP. Interference with the complement of PRS genes in S. cerevisiae has far-reaching consequences for yeast physiology and has uncovered unexpected metabolic links including cell wall integrity and phospholipid metabolism. ©2005 Biochemical Society.

Original language	English
Pages (from-to)	1154-1157
Number of pages	4
Journal	Biochemical Society Transactions
Volume	33
Issue number	5
DOIs	https://doi.org/10.1042/BST20051154
Publication status	Published - Nov 2005

Keywords

CTP
Metabolic networking
Prs (phosphoribosylpyropliosphate synthetase)
Slt2
Socchoromyces cerevisiae
Valproate

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10.1042/BST20051154

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title = "In Sacchoromyces cerevisiae, impaired PRPP synthesis is accompanied by valproate and Li+ sensitivity",

abstract = "The biosynthetic intermediate PRPP (phosphoribosylpyrophosphate) has a central role in cellular biochemistry since it links carbon and nitrogen metabolism. Its importance may be reflected in the fact that, in the Saccharomyces cerevisiae (yeast) genome, there are five unlinked genes, PRS1-PRS5, each of which is theoretically capable of encoding the enzyme synthesizing PRPP. Interference with the complement of PRS genes in S. cerevisiae has far-reaching consequences for yeast physiology and has uncovered unexpected metabolic links including cell wall integrity and phospholipid metabolism. {\textcopyright}2005 Biochemical Society.",

keywords = "CTP, Metabolic networking, Prs (phosphoribosylpyropliosphate synthetase), Slt2, Socchoromyces cerevisiae, Valproate",

author = "S. Vavassori and K. Wang and Schweizer, {L. M.} and M. Schweizer",

year = "2005",

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language = "English",

volume = "33",

pages = "1154--1157",

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TY - JOUR

T1 - In Sacchoromyces cerevisiae, impaired PRPP synthesis is accompanied by valproate and Li+ sensitivity

AU - Vavassori, S.

AU - Wang, K.

AU - Schweizer, L. M.

AU - Schweizer, M.

PY - 2005/11

Y1 - 2005/11

N2 - The biosynthetic intermediate PRPP (phosphoribosylpyrophosphate) has a central role in cellular biochemistry since it links carbon and nitrogen metabolism. Its importance may be reflected in the fact that, in the Saccharomyces cerevisiae (yeast) genome, there are five unlinked genes, PRS1-PRS5, each of which is theoretically capable of encoding the enzyme synthesizing PRPP. Interference with the complement of PRS genes in S. cerevisiae has far-reaching consequences for yeast physiology and has uncovered unexpected metabolic links including cell wall integrity and phospholipid metabolism. ©2005 Biochemical Society.

AB - The biosynthetic intermediate PRPP (phosphoribosylpyrophosphate) has a central role in cellular biochemistry since it links carbon and nitrogen metabolism. Its importance may be reflected in the fact that, in the Saccharomyces cerevisiae (yeast) genome, there are five unlinked genes, PRS1-PRS5, each of which is theoretically capable of encoding the enzyme synthesizing PRPP. Interference with the complement of PRS genes in S. cerevisiae has far-reaching consequences for yeast physiology and has uncovered unexpected metabolic links including cell wall integrity and phospholipid metabolism. ©2005 Biochemical Society.

KW - CTP

KW - Metabolic networking

KW - Prs (phosphoribosylpyropliosphate synthetase)

KW - Slt2

KW - Socchoromyces cerevisiae

KW - Valproate

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U2 - 10.1042/BST20051154

DO - 10.1042/BST20051154

M3 - Article

C2 - 16246070

SN - 0300-5127

VL - 33

SP - 1154

EP - 1157

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 5

ER -

In Sacchoromyces cerevisiae, impaired PRPP synthesis is accompanied by valproate and Li⁺ sensitivity

Abstract

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