Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization

Xianfeng Chen, Germain J.P. Fernando, Michael L. Crichton, Christopher Flaim, Sally R. Yukiko, Emily J. Fairmaid, Holly J. Corbett, Clare A. Primiero, Alexander B. Ansaldo, Ian H. Frazer, Lorena E. Brown, Mark A.F. Kendall

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Dry-coated microprojections can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient immune responses and the dry-coated vaccines are expected to be thermostable at elevated temperatures. In this paper, we show that we have dramatically improved our previously reported gas-jet drying coating method and greatly increased the delivery efficiency of coating from patch to skin to from 6.5% to 32.5%, by both varying the coating parameters and removing the patch edge. Combined with our previous dose sparing report of influenza vaccine delivery in a mouse model, the results show that we now achieve equivalent protective immune responses as intramuscular injection (with the needle and syringe), but with only 1/30th of the actual dose. We also show that influenza vaccine coated microprojection patches are stable for at least 6 months at 23 °C, inducing comparable immunogenicity with freshly coated patches. The dry-coated microprojection patches thus have key and unique attributes in ultimately meeting the medical need in certain low-resource regions with low vaccine affordability and difficulty in maintaining "cold-chain" for vaccine storage and transport.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalJournal of Controlled Release
Volume152
Issue number3
DOIs
Publication statusPublished - 30 Jun 2011

Keywords

  • Microprojection
  • Thermostability
  • Vaccine coating

ASJC Scopus subject areas

  • Pharmaceutical Science

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