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Abstract

In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because Ipo11 mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor.

Original languageEnglish
Pages (from-to)539-541
Number of pages3
JournalJournal of Cell Biology
Volume216
Issue number3
Early online date13 Feb 2017
DOIs
Publication statusPublished - Mar 2017

ASJC Scopus subject areas

  • Cell Biology

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