Importin-11 keeps PTEN safe from harm

Nick R. Leslie

doi:10.1083/jcb.201612014

Importin-11 keeps PTEN safe from harm

Nick R. Leslie

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Abstract

In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because Ipo11 mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor.

Original language	English
Pages (from-to)	539-541
Number of pages	3
Journal	Journal of Cell Biology
Volume	216
Issue number	3
Early online date	13 Feb 2017
DOIs	https://doi.org/10.1083/jcb.201612014
Publication status	Published - Mar 2017

ASJC Scopus subject areas

Cell Biology

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© 2017 Leslie This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
Final published version, 570 KBLicence: CC BY-NC-SA

Cite this

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abstract = "In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because Ipo11 mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor.",

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AB - In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because Ipo11 mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor.

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Importin-11 keeps PTEN safe from harm

Abstract

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