TY - JOUR
T1 - Impact of temporomandibular joint complaints on tinnitus-related distress
AU - Edvall, Niklas K.
AU - Gunan, Edis
AU - Genitsaridi, Eleni
AU - Lazar, Andra
AU - Mehraei, Golbarg
AU - Billing, Mattias
AU - Tullberg, Marie
AU - Bulla, Jan
AU - Whitton, Jonathon
AU - Canlon, Barbara
AU - Hall, Deborah A.
AU - Cederroth, Christopher R.
N1 - Funding Information:
BC has received funding from the Swedish Medical Research Council (K2014-99X-22478-01-3), Karolinska Institutet, and Tysta Skolan. CC has received research funding from the Decibel Therapeutics, Inc., Svenska L?kares?llskapet (SLS-779681), Tysta Skolan, H?rselforskningsfonden (#503), the European Union?s Horizon 2020 Research and Innovation Programme under the Marie Sk?odowska-Curie grant agreement no. 72204655 (Schlee et al., 2017b), and the GENDER-NET Co-Plus Fund (GNP-182). DH is a NIHR Senior Investigator.
Publisher Copyright:
© 2019 Edvall, Gunan, Genitsaridi, Lazar, Mehraei, Billing, Tullberg, Bulla, Whitton, Canlon, Hall and Cederroth.
PY - 2019/8/22
Y1 - 2019/8/22
N2 - There is increasing evidence of associations between the presence of temporomandibular joint (TMJ) disorders and tinnitus. It has been recently proposed that tinnitus patients with TMJ complaints could constitute a subtype, meaning a subgroup of tinnitus patients responsive to specific treatments. Tinnitus patients with TMJ complaints are often young women with somatosensory features of their tinnitus. Here, we investigate the socio-economic factors, phenotypic characteristics and psychological variables of tinnitus subjects from the Swedish Tinnitus Outreach Project, with (n = 486) or without (n = 1,996) TMJ complaints. The prevalence of TMJ complaints was greater in tinnitus subjects with severe tinnitus (36%) when compared to those with any tinnitus (19%), strongly indicating the contribution of TMJ problems to the severity of tinnitus. Comparing subgroups with or without TMJ complaints in the whole sample, differences were found regarding a large number of socioeconomic, phenotypic, and psychological characteristics. Subjects with TMJ complaints were more often women, more often reported stress as the cause of tinnitus, were more severely affected by tinnitus, scored worse in measures of psychological well-being and life quality, and were more often affected by problems tolerating sounds, headache, vertigo/dizziness, and neck pain. In addition, they more often reported pulsating and tonal tinnitus, somatic modulation of tinnitus, and aggravation of tinnitus by loud sounds and stress. When focusing the analysis in subjects with tinnitus as a big problem using the Tinnitus Functional Index cut-off ≥ 48, or with severe tinnitus according to the Tinnitus Handicap Inventory cut-off ≥ 58, the impact of somatosensory modulations and stress on tinnitus were greater in subjects with TMJ complaints in comparison to those without. In light of these results, we hypothesize that stress could contribute to the co-occurrence of TMJ problems and tinnitus and also to the development of severe tinnitus. Our study supports the need of involving dental care and stress management in the holistic treatment of patients with severe tinnitus.
AB - There is increasing evidence of associations between the presence of temporomandibular joint (TMJ) disorders and tinnitus. It has been recently proposed that tinnitus patients with TMJ complaints could constitute a subtype, meaning a subgroup of tinnitus patients responsive to specific treatments. Tinnitus patients with TMJ complaints are often young women with somatosensory features of their tinnitus. Here, we investigate the socio-economic factors, phenotypic characteristics and psychological variables of tinnitus subjects from the Swedish Tinnitus Outreach Project, with (n = 486) or without (n = 1,996) TMJ complaints. The prevalence of TMJ complaints was greater in tinnitus subjects with severe tinnitus (36%) when compared to those with any tinnitus (19%), strongly indicating the contribution of TMJ problems to the severity of tinnitus. Comparing subgroups with or without TMJ complaints in the whole sample, differences were found regarding a large number of socioeconomic, phenotypic, and psychological characteristics. Subjects with TMJ complaints were more often women, more often reported stress as the cause of tinnitus, were more severely affected by tinnitus, scored worse in measures of psychological well-being and life quality, and were more often affected by problems tolerating sounds, headache, vertigo/dizziness, and neck pain. In addition, they more often reported pulsating and tonal tinnitus, somatic modulation of tinnitus, and aggravation of tinnitus by loud sounds and stress. When focusing the analysis in subjects with tinnitus as a big problem using the Tinnitus Functional Index cut-off ≥ 48, or with severe tinnitus according to the Tinnitus Handicap Inventory cut-off ≥ 58, the impact of somatosensory modulations and stress on tinnitus were greater in subjects with TMJ complaints in comparison to those without. In light of these results, we hypothesize that stress could contribute to the co-occurrence of TMJ problems and tinnitus and also to the development of severe tinnitus. Our study supports the need of involving dental care and stress management in the holistic treatment of patients with severe tinnitus.
KW - Distress
KW - Somato sensory
KW - Stress
KW - Tinnitus
KW - TMJ
UR - http://www.scopus.com/inward/record.url?scp=85072065221&partnerID=8YFLogxK
U2 - 10.3389/fnins.2019.00879
DO - 10.3389/fnins.2019.00879
M3 - Article
AN - SCOPUS:85072065221
SN - 1662-4548
VL - 13
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
M1 - 879
ER -
