Impact of small vessel disease in the brain on gait and balance

Daniela Pinter, Stuart J. Ritchie, Fergus Doubal, Thomas Gattringer, Zoe Morris, Mark E. Bastin, Maria Del C Valdés Hernández, Natalie A. Royle, Janie Corley, Susana Muñoz Maniega, Alison Pattie, David A. Dickie, Julie Staals, Alan J. Gow, John M. Starr, Ian J. Deary, Christian Enzinger, Franz Fazekas, Joanna Wardlaw

Abstract

Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain gait and balance function in the elderly. We analysed 678 community-dwelling healthy subjects from the Lothian Birth Cohort 1936 at the age of 71-74 years who had undergone comprehensive risk factor assessment, gait and balance assessment as well as brain MRI. We investigated the impact of individual SVD markers (white matter hyperintensity - WMH, microbleeds, lacunes, enlarged perivascular spaces, brain atrophy) as seen on structural brain MRI and of a global SVD score on the patients' performance. A regression model revealed that age, sex, and hypertension significantly explained gait speed. Among SVD markers white matter hyperintensity (WMH) score or volume were additional significant and independent predictors of gait speed in the regression model. A similar association was seen with the global SVD score. Our study confirms a negative impact of SVD-related morphologic brain changes on gait speed in addition to age, sex and hypertension independent from brain atrophy. The presence of WMH seems to be the major driving force for SVD on gait impairment in healthy elderly subjects.

Original languageEnglish
Article number41637
JournalScientific Reports
Volume7
DOIs
StatePublished - 30 Jan 2017

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Brain Diseases
Gait
vessel
brain
Brain
White Matter
balance
speed
score
age
impact
Atrophy
Healthy Volunteers
Hypertension
hypertension
elderly
regression
subject
assessment
model

Cite this

Pinter, D., Ritchie, S. J., Doubal, F., Gattringer, T., Morris, Z., Bastin, M. E., ... Wardlaw, J. (2017). Impact of small vessel disease in the brain on gait and balance. Scientific Reports, 7, [41637]. DOI: 10.1038/srep41637

Pinter, Daniela; Ritchie, Stuart J.; Doubal, Fergus; Gattringer, Thomas; Morris, Zoe; Bastin, Mark E.; Hernández, Maria Del C Valdés; Royle, Natalie A.; Corley, Janie; Muñoz Maniega, Susana; Pattie, Alison; Dickie, David A.; Staals, Julie; Gow, Alan J.; Starr, John M.; Deary, Ian J.; Enzinger, Christian; Fazekas, Franz; Wardlaw, Joanna / Impact of small vessel disease in the brain on gait and balance.

In: Scientific Reports, Vol. 7, 41637, 30.01.2017.

Research output: Contribution to journalArticle

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title = "Impact of small vessel disease in the brain on gait and balance",
author = "Daniela Pinter and Ritchie, {Stuart J.} and Fergus Doubal and Thomas Gattringer and Zoe Morris and Bastin, {Mark E.} and Hernández, {Maria Del C Valdés} and Royle, {Natalie A.} and Janie Corley and {Muñoz Maniega}, Susana and Alison Pattie and Dickie, {David A.} and Julie Staals and Gow, {Alan J.} and Starr, {John M.} and Deary, {Ian J.} and Christian Enzinger and Franz Fazekas and Joanna Wardlaw",
year = "2017",
month = "1",
doi = "10.1038/srep41637",
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journal = "Scientific Reports",
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Pinter, D, Ritchie, SJ, Doubal, F, Gattringer, T, Morris, Z, Bastin, ME, Hernández, MDCV, Royle, NA, Corley, J, Muñoz Maniega, S, Pattie, A, Dickie, DA, Staals, J, Gow, AJ, Starr, JM, Deary, IJ, Enzinger, C, Fazekas, F & Wardlaw, J 2017, 'Impact of small vessel disease in the brain on gait and balance' Scientific Reports, vol 7, 41637. DOI: 10.1038/srep41637

Impact of small vessel disease in the brain on gait and balance. / Pinter, Daniela; Ritchie, Stuart J.; Doubal, Fergus; Gattringer, Thomas; Morris, Zoe; Bastin, Mark E.; Hernández, Maria Del C Valdés; Royle, Natalie A.; Corley, Janie; Muñoz Maniega, Susana; Pattie, Alison; Dickie, David A.; Staals, Julie; Gow, Alan J.; Starr, John M.; Deary, Ian J.; Enzinger, Christian; Fazekas, Franz; Wardlaw, Joanna.

In: Scientific Reports, Vol. 7, 41637, 30.01.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of small vessel disease in the brain on gait and balance

AU - Pinter,Daniela

AU - Ritchie,Stuart J.

AU - Doubal,Fergus

AU - Gattringer,Thomas

AU - Morris,Zoe

AU - Bastin,Mark E.

AU - Hernández,Maria Del C Valdés

AU - Royle,Natalie A.

AU - Corley,Janie

AU - Muñoz Maniega,Susana

AU - Pattie,Alison

AU - Dickie,David A.

AU - Staals,Julie

AU - Gow,Alan J.

AU - Starr,John M.

AU - Deary,Ian J.

AU - Enzinger,Christian

AU - Fazekas,Franz

AU - Wardlaw,Joanna

PY - 2017/1/30

Y1 - 2017/1/30

N2 - Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain gait and balance function in the elderly. We analysed 678 community-dwelling healthy subjects from the Lothian Birth Cohort 1936 at the age of 71-74 years who had undergone comprehensive risk factor assessment, gait and balance assessment as well as brain MRI. We investigated the impact of individual SVD markers (white matter hyperintensity - WMH, microbleeds, lacunes, enlarged perivascular spaces, brain atrophy) as seen on structural brain MRI and of a global SVD score on the patients' performance. A regression model revealed that age, sex, and hypertension significantly explained gait speed. Among SVD markers white matter hyperintensity (WMH) score or volume were additional significant and independent predictors of gait speed in the regression model. A similar association was seen with the global SVD score. Our study confirms a negative impact of SVD-related morphologic brain changes on gait speed in addition to age, sex and hypertension independent from brain atrophy. The presence of WMH seems to be the major driving force for SVD on gait impairment in healthy elderly subjects.

AB - Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain gait and balance function in the elderly. We analysed 678 community-dwelling healthy subjects from the Lothian Birth Cohort 1936 at the age of 71-74 years who had undergone comprehensive risk factor assessment, gait and balance assessment as well as brain MRI. We investigated the impact of individual SVD markers (white matter hyperintensity - WMH, microbleeds, lacunes, enlarged perivascular spaces, brain atrophy) as seen on structural brain MRI and of a global SVD score on the patients' performance. A regression model revealed that age, sex, and hypertension significantly explained gait speed. Among SVD markers white matter hyperintensity (WMH) score or volume were additional significant and independent predictors of gait speed in the regression model. A similar association was seen with the global SVD score. Our study confirms a negative impact of SVD-related morphologic brain changes on gait speed in addition to age, sex and hypertension independent from brain atrophy. The presence of WMH seems to be the major driving force for SVD on gait impairment in healthy elderly subjects.

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Pinter D, Ritchie SJ, Doubal F, Gattringer T, Morris Z, Bastin ME et al. Impact of small vessel disease in the brain on gait and balance. Scientific Reports. 2017 Jan 30;7. 41637. Available from, DOI: 10.1038/srep41637