Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run

Elisa Couto Gomes, Vicki Stone, Geraint Florida-James

    Research output: Contribution to journalArticle

    Abstract

    To investigate the acute effect of a hot, humid and ozone-polluted (O-3) environment on lung inflammation and oxidative tress of runners performing 8 km time trial run. Using a single-blinded randomized design, 10 male athletes (mean (V) over dotO(2max) = 64.4 mlO(2) kg(-1) min(-1), SD = 4.4) took part in a time trial run in four different environmental conditions: 20 degrees C + 50% relative humidity (rh) (Control); 20 degrees C + 50% rh + 0.10 ppm O-3 (Control + O-3); 31 degrees C + 70% rh (Heat); 31 degrees C + 70% rh + 0.10 ppm O-3 (Heat + O-3). Blood samples and nasal lavage were collected post-exercise and analyzed for inflammatory, epithelial damage and oxidative stress markers. Data were analyzed using repeated measures ANOVA with Tukey's post hoc test. A significant increase in CC16 concentration (P < 0.05) and GSH/protein concentration (P < 0.05) in the upper respiratory airways was observed following the 8 km run in the Heat + O-3 trial compared with the control trial. There were no differences in the neutrophil counts between trials. No differences were observed for the other antioxidants analyzed. A hot, humid and ozone-polluted environment (0.1 ppm) elicits an early epithelial damage and antioxidant protection process in the upper respiratory airways of athletes immediately after performing 8 km time trial run.

    Original languageEnglish
    Pages (from-to)2089-2097
    Number of pages9
    JournalEuropean Journal of Applied Physiology and Occupational Physiology
    Volume111
    Issue number9
    DOIs
    Publication statusPublished - Sep 2011

    Cite this

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    title = "Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run",
    abstract = "To investigate the acute effect of a hot, humid and ozone-polluted (O-3) environment on lung inflammation and oxidative tress of runners performing 8 km time trial run. Using a single-blinded randomized design, 10 male athletes (mean (V) over dotO(2max) = 64.4 mlO(2) kg(-1) min(-1), SD = 4.4) took part in a time trial run in four different environmental conditions: 20 degrees C + 50{\%} relative humidity (rh) (Control); 20 degrees C + 50{\%} rh + 0.10 ppm O-3 (Control + O-3); 31 degrees C + 70{\%} rh (Heat); 31 degrees C + 70{\%} rh + 0.10 ppm O-3 (Heat + O-3). Blood samples and nasal lavage were collected post-exercise and analyzed for inflammatory, epithelial damage and oxidative stress markers. Data were analyzed using repeated measures ANOVA with Tukey's post hoc test. A significant increase in CC16 concentration (P < 0.05) and GSH/protein concentration (P < 0.05) in the upper respiratory airways was observed following the 8 km run in the Heat + O-3 trial compared with the control trial. There were no differences in the neutrophil counts between trials. No differences were observed for the other antioxidants analyzed. A hot, humid and ozone-polluted environment (0.1 ppm) elicits an early epithelial damage and antioxidant protection process in the upper respiratory airways of athletes immediately after performing 8 km time trial run.",
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    Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run. / Gomes, Elisa Couto; Stone, Vicki; Florida-James, Geraint.

    In: European Journal of Applied Physiology and Occupational Physiology, Vol. 111, No. 9, 09.2011, p. 2089-2097.

    Research output: Contribution to journalArticle

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    AB - To investigate the acute effect of a hot, humid and ozone-polluted (O-3) environment on lung inflammation and oxidative tress of runners performing 8 km time trial run. Using a single-blinded randomized design, 10 male athletes (mean (V) over dotO(2max) = 64.4 mlO(2) kg(-1) min(-1), SD = 4.4) took part in a time trial run in four different environmental conditions: 20 degrees C + 50% relative humidity (rh) (Control); 20 degrees C + 50% rh + 0.10 ppm O-3 (Control + O-3); 31 degrees C + 70% rh (Heat); 31 degrees C + 70% rh + 0.10 ppm O-3 (Heat + O-3). Blood samples and nasal lavage were collected post-exercise and analyzed for inflammatory, epithelial damage and oxidative stress markers. Data were analyzed using repeated measures ANOVA with Tukey's post hoc test. A significant increase in CC16 concentration (P < 0.05) and GSH/protein concentration (P < 0.05) in the upper respiratory airways was observed following the 8 km run in the Heat + O-3 trial compared with the control trial. There were no differences in the neutrophil counts between trials. No differences were observed for the other antioxidants analyzed. A hot, humid and ozone-polluted environment (0.1 ppm) elicits an early epithelial damage and antioxidant protection process in the upper respiratory airways of athletes immediately after performing 8 km time trial run.

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