Immobilization of saponin on chitosan Milli-particles for Type II diabetic treatment

Maxine Yew; Chang Nong Lim; Boon Aik Liam; Kai Seng Koh; Siew Shee Lim; Billie Hiew; Ju Yen Fu

doi:10.1016/j.matlet.2023.134686

Immobilization of saponin on chitosan Milli-particles for Type II diabetic treatment

Maxine Yew, Chang Nong Lim, Boon Aik Liam, Kai Seng Koh, Siew Shee Lim, Billie Hiew, Ju Yen Fu

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Type II diabetes mellitus (T2DM) has caused an adverse impact on the health of more than a tenth of the Malaysian population. Saponin is a traditional herbal extract found to be effective in treating T2DM with milder toxicity, which makes it a good alternative to conventional anti-diabetic drugs with side effects. This research develops an effective drug delivery vehicle to transport the saponin extract via chitosan milli-particles (CPs) for targeted release in the digestive system. Saponin was loaded onto the CPs via electrostatic interaction following the surface charge alteration of the CPs. Swelling tests and an in vitro study based on simulated gastrointestinal conditions were conducted on the saponin-immobilized CPs (SICPs). The release of saponin from its carrier is attributed to Fickian diffusion and swelling of the chitosan milli-particle matrix at pH 1.2 and 6.8.

Original language	English
Article number	134686
Journal	Materials Letters
Volume	348
Early online date	5 Jun 2023
DOIs	https://doi.org/10.1016/j.matlet.2023.134686
Publication status	E-pub ahead of print - 5 Jun 2023

Keywords

Biomaterial
Chitosan
Diabetes
Milli-fluidic
Saponin
Surfaces

ASJC Scopus subject areas

Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering
Materials Science(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Immobilization of saponin on chitosan Milli-particles for Type II diabetic treatment",

abstract = "Type II diabetes mellitus (T2DM) has caused an adverse impact on the health of more than a tenth of the Malaysian population. Saponin is a traditional herbal extract found to be effective in treating T2DM with milder toxicity, which makes it a good alternative to conventional anti-diabetic drugs with side effects. This research develops an effective drug delivery vehicle to transport the saponin extract via chitosan milli-particles (CPs) for targeted release in the digestive system. Saponin was loaded onto the CPs via electrostatic interaction following the surface charge alteration of the CPs. Swelling tests and an in vitro study based on simulated gastrointestinal conditions were conducted on the saponin-immobilized CPs (SICPs). The release of saponin from its carrier is attributed to Fickian diffusion and swelling of the chitosan milli-particle matrix at pH 1.2 and 6.8.",

keywords = "Biomaterial, Chitosan, Diabetes, Milli-fluidic, Saponin, Surfaces",

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AU - Yew, Maxine

AU - Lim, Chang Nong

AU - Liam, Boon Aik

AU - Koh, Kai Seng

AU - Lim, Siew Shee

AU - Hiew, Billie

AU - Fu, Ju Yen

PY - 2023/6/5

Y1 - 2023/6/5

N2 - Type II diabetes mellitus (T2DM) has caused an adverse impact on the health of more than a tenth of the Malaysian population. Saponin is a traditional herbal extract found to be effective in treating T2DM with milder toxicity, which makes it a good alternative to conventional anti-diabetic drugs with side effects. This research develops an effective drug delivery vehicle to transport the saponin extract via chitosan milli-particles (CPs) for targeted release in the digestive system. Saponin was loaded onto the CPs via electrostatic interaction following the surface charge alteration of the CPs. Swelling tests and an in vitro study based on simulated gastrointestinal conditions were conducted on the saponin-immobilized CPs (SICPs). The release of saponin from its carrier is attributed to Fickian diffusion and swelling of the chitosan milli-particle matrix at pH 1.2 and 6.8.

AB - Type II diabetes mellitus (T2DM) has caused an adverse impact on the health of more than a tenth of the Malaysian population. Saponin is a traditional herbal extract found to be effective in treating T2DM with milder toxicity, which makes it a good alternative to conventional anti-diabetic drugs with side effects. This research develops an effective drug delivery vehicle to transport the saponin extract via chitosan milli-particles (CPs) for targeted release in the digestive system. Saponin was loaded onto the CPs via electrostatic interaction following the surface charge alteration of the CPs. Swelling tests and an in vitro study based on simulated gastrointestinal conditions were conducted on the saponin-immobilized CPs (SICPs). The release of saponin from its carrier is attributed to Fickian diffusion and swelling of the chitosan milli-particle matrix at pH 1.2 and 6.8.

KW - Biomaterial

KW - Chitosan

KW - Diabetes

KW - Milli-fluidic

KW - Saponin

KW - Surfaces

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DO - 10.1016/j.matlet.2023.134686

M3 - Article

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JO - Materials Letters

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M1 - 134686

ER -

Immobilization of saponin on chitosan Milli-particles for Type II diabetic treatment

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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