Lawsonia intracellularis: getting inside the pathogenesis of proliferative enteropathy

David George Emslie Smith; G. H. K. Lawson

doi:10.1016/S0378-1135(01)00397-2

Lawsonia intracellularis: getting inside the pathogenesis of proliferative enteropathy

David George Emslie Smith, G. H. K. Lawson

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Although proliferative enteropathy (PE) has been recognised for several decades, Lawsonia intracellularis, the aetiological agent, was identified formally in only 1995. This organism is both highly fastidious and obligately intracellular bacterium, characteristics which have inevitably restricted investigations in all aspects of its biology. Despite these limitations, advances have been made in characterising and understanding L. intracellularis-host interaction both in vivo and in vitro. Based upon evidence provided by mainly pathological and histological investigations conducted to date, we review salient features of our current understanding of processes involved throughout the course of infection by this unique pathogen.

Original language	English
Pages (from-to)	331-345
Number of pages	15
Journal	Veterinary Microbiology
Volume	82
Issue number	4
DOIs	https://doi.org/10.1016/S0378-1135(01)00397-2
Publication status	Published - 1 Oct 2001

Keywords

Animals
Bacterial Adhesion
Bacterial Physiological Phenomena
Enteritis
Gram-Negative Bacterial Infections
Hyperplasia
Intestinal Mucosa
Lawsonia Bacteria

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abstract = "Although proliferative enteropathy (PE) has been recognised for several decades, Lawsonia intracellularis, the aetiological agent, was identified formally in only 1995. This organism is both highly fastidious and obligately intracellular bacterium, characteristics which have inevitably restricted investigations in all aspects of its biology. Despite these limitations, advances have been made in characterising and understanding L. intracellularis-host interaction both in vivo and in vitro. Based upon evidence provided by mainly pathological and histological investigations conducted to date, we review salient features of our current understanding of processes involved throughout the course of infection by this unique pathogen.",

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AU - Lawson, G. H. K.

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N2 - Although proliferative enteropathy (PE) has been recognised for several decades, Lawsonia intracellularis, the aetiological agent, was identified formally in only 1995. This organism is both highly fastidious and obligately intracellular bacterium, characteristics which have inevitably restricted investigations in all aspects of its biology. Despite these limitations, advances have been made in characterising and understanding L. intracellularis-host interaction both in vivo and in vitro. Based upon evidence provided by mainly pathological and histological investigations conducted to date, we review salient features of our current understanding of processes involved throughout the course of infection by this unique pathogen.

AB - Although proliferative enteropathy (PE) has been recognised for several decades, Lawsonia intracellularis, the aetiological agent, was identified formally in only 1995. This organism is both highly fastidious and obligately intracellular bacterium, characteristics which have inevitably restricted investigations in all aspects of its biology. Despite these limitations, advances have been made in characterising and understanding L. intracellularis-host interaction both in vivo and in vitro. Based upon evidence provided by mainly pathological and histological investigations conducted to date, we review salient features of our current understanding of processes involved throughout the course of infection by this unique pathogen.

KW - Animals

KW - Bacterial Adhesion

KW - Bacterial Physiological Phenomena

KW - Enteritis

KW - Gram-Negative Bacterial Infections

KW - Hyperplasia

KW - Intestinal Mucosa

KW - Lawsonia Bacteria

U2 - 10.1016/S0378-1135(01)00397-2

DO - 10.1016/S0378-1135(01)00397-2

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JO - Veterinary Microbiology

JF - Veterinary Microbiology

SN - 0378-1135

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