TY - JOUR
T1 - Crocodylus porosus Gut Bacteria: A Possible Source of Novel Metabolites
AU - Khan, Naveed Ahmed
AU - Soopramanien, Morhanavallee
AU - Maciver, Sutherland Kester
AU - Anuar, Tengku Shahrul
AU - Sagathevan, Kuppusamy
AU - Siddiqui, Ruqaiyyah
PY - 2021/8/18
Y1 - 2021/8/18
N2 - Crocodiles are remarkable animals that have the ability to endure extremely harsh conditions and can survive up to a 100 years while being exposed to noxious agents that are detrimental to Homo sapiens. Besides their immunity, we postulate that the microbial gut flora of crocodiles may produce substances with protective effects. In this study, we isolated and characterized selected bacteria colonizing the gastrointestinal tract of Crocodylus porosus and demonstrated their inhibitory effects against three different cancerous cell lineages. Using liquid chromatography-mass spectrometry, several molecules were identified. For the first time, we report partial analyses of crocodile’s gut bacterial molecules.
AB - Crocodiles are remarkable animals that have the ability to endure extremely harsh conditions and can survive up to a 100 years while being exposed to noxious agents that are detrimental to Homo sapiens. Besides their immunity, we postulate that the microbial gut flora of crocodiles may produce substances with protective effects. In this study, we isolated and characterized selected bacteria colonizing the gastrointestinal tract of Crocodylus porosus and demonstrated their inhibitory effects against three different cancerous cell lineages. Using liquid chromatography-mass spectrometry, several molecules were identified. For the first time, we report partial analyses of crocodile’s gut bacterial molecules.
U2 - 10.3390/molecules26164999
DO - 10.3390/molecules26164999
M3 - Article
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 16
M1 - 4999
ER -
