Crocodylus porosus Gut Bacteria: A Possible Source of Novel Metabolites

Naveed Ahmed Khan, Morhanavallee Soopramanien, Sutherland Kester Maciver, Tengku Shahrul Anuar, Kuppusamy Sagathevan, Ruqaiyyah Siddiqui

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
2 Downloads (Pure)

Abstract

Crocodiles are remarkable animals that have the ability to endure extremely harsh conditions and can survive up to a 100 years while being exposed to noxious agents that are detrimental to Homo sapiens. Besides their immunity, we postulate that the microbial gut flora of crocodiles may produce substances with protective effects. In this study, we isolated and characterized selected bacteria colonizing the gastrointestinal tract of Crocodylus porosus and demonstrated their inhibitory effects against three different cancerous cell lineages. Using liquid chromatography-mass spectrometry, several molecules were identified. For the first time, we report partial analyses of crocodile’s gut bacterial molecules.
Original languageEnglish
Article number4999
JournalMolecules
Volume26
Issue number16
DOIs
Publication statusPublished - 18 Aug 2021

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